Compounds and compositions for prevention of overdose of oxycodone
First Claim
1. A pharmaceutical composition comprising oxycodone, or a pharmaceutically acceptable salt thereof, covalently bound to an amino acid, or to an oligopeptide of 12 or fewer amino acids, at the 6′
- position and the 14′
position of said oxycodone and one or more pharmaceutically acceptable additives, wherein said composition is in a dosage form suitable for oral delivery.
2 Assignments
0 Petitions
Accused Products
Abstract
The invention relates to pharmaceutical compounds and compositions comprised of a chemical moiety attached to an opioid such as oxycodone in a manner that substantially decreases the potential of the opioid to cause overdose. When delivered at the proper dosage the pharmaceutical composition provides therapeutic activity similar to that of the parent active agent. Further the compounds and compositions of the invention are useful in preventing addiction and susceptibility to addiction.
122 Citations
102 Claims
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1. A pharmaceutical composition comprising oxycodone, or a pharmaceutically acceptable salt thereof, covalently bound to an amino acid, or to an oligopeptide of 12 or fewer amino acids, at the 6′
- position and the 14′
position of said oxycodone and one or more pharmaceutically acceptable additives, wherein said composition is in a dosage form suitable for oral delivery. - View Dependent Claims (2, 3, 8, 9, 10, 11, 12, 13, 14, 15, 16, 18, 19, 39, 40, 41)
- position and the 14′
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4-7. -7. (canceled)
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17. (canceled)
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20-38. -38. (canceled)
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42-101. -101. (canceled)
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102. A pharmaceutical composition comprising oxycodone, or a pharmaceutically acceptable salt thereof, covalently bound to an amino acid, or to an oligopeptide of 12 or fewer amino acids, at the 6′
- position of said oxycodone, and one or more pharmaceutically acceptable additives, wherein said composition is in a dosage form suitable for oral delivery.
Specification