Compositions containing fast-leaching plasticizers for improved performance of medical devices
First Claim
1. A method of producing a medical article comprising a temporary plasticizing agent, wherein the method comprises combining a polymer with a plasticizing agent capable of sufficiently increasing a strain-to-failure in the polymeric material to prevent or reduce a formation of cracks in the polymeric material while placing an implant in a subject, wherein the plasticizing agent leaches from the polymeric material after placing the implant in the subject to provide a sufficient rigidity in the polymeric material, and wherein the plasticizing agent leaches from the polymeric material in less than an amount of time necessary for a required dimension of the implant to change substantially in response to a stress.
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Abstract
Medical implants containing a temporary plasticizer, methods of producing such implants, and methods of using the implants in treating a disease, or ameliorating one or more symptoms thereof, in a subject are provided.
138 Citations
19 Claims
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1. A method of producing a medical article comprising a temporary plasticizing agent, wherein the method comprises
combining a polymer with a plasticizing agent capable of sufficiently increasing a strain-to-failure in the polymeric material to prevent or reduce a formation of cracks in the polymeric material while placing an implant in a subject, wherein the plasticizing agent leaches from the polymeric material after placing the implant in the subject to provide a sufficient rigidity in the polymeric material, and wherein the plasticizing agent leaches from the polymeric material in less than an amount of time necessary for a required dimension of the implant to change substantially in response to a stress.
Specification