Endovascular device with membrane having permanently attached agents

• US 20070203573A1
• Filed: 12/12/2006
• Published: 08/30/2007
• Est. Priority Date: 12/13/2005
• Status: Abandoned Application

• Current Assignee: Merlin MD Pte. Ltd.
• Original Assignee: Merlin MD Pte. Ltd.
• Inventors: Rudakov, Leon, Hong, Tsui Ying, Sung, Peir
• Application Number:
  US11/637,188
• Publication Number:
  US 20070203573A1
• Time in Patent Office: Days
• US Class Current: 623/1.440
• CPC Class Codes: A61F 2/07 Stent-grafts
• CPC Class Codes: A61F 2002/075 the stent being loosely attached to the graft material, e.g. by stitching
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61L 2300/40 characterised by a specific therapeutic activity or mode of action
• CPC Class Codes: A61L 2400/18 Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence

Abstract

An endovascular device (10) for treatment of a bodily vessel (5) of a patient at a surgical site, the endovascular device (10) comprising: a mechanically expandable device (11) expandable from a first position to a second position, said mechanically expandable device (11) is expanded radially outwardly to the second position such that the circumferential surface of said mechanically expandable device (11) engages with the inner surface of the vessel (5) so as to maintain a fluid pathway through said vessel (5); and a membrane (15) secured to a portion of the circumferential surface of said mechanically expandable device (11); wherein at least one capture agent (20, 21) is permanently attached to the lumenal surface of the membrane (15) to capture a predetermined target component from blood passing through the fluid pathway; and at least one signal agent (22) is permanently attached to the lumenal surface of the membrane (15) to signal the captured target component to up regulate or down regulate a cell function of the captured target component to enhance endothelialization and healing.

Claims

1. An endovascular device for treatment of a bodily vessel of a patient at a surgical site, the endovascular device comprising:

a mechanically expandable device expandable from a first position to a second position, said mechanically expandable device is expanded radially outwardly to the second position such that the circumferential surface of said mechanically expandable device engages with the inner surface of the vessel so as to maintain a fluid pathway through said vessel; and

a membrane secured to a portion of the circumferential surface of said mechanically expandable device;

wherein at least one capture agent is permanently attached to the lumenal surface of the membrane to capture a predetermined target component from blood passing through the fluid pathway; and

at least one signal agent is permanently attached to the lumenal surface of the membrane to signal the captured target component to up regulate or down regulate a cell function of the captured target component to enhance endothelialization and healing.

2. The device according to claim 1, wherein the cell function is any one from the group consisting of:

proliferation, migration, maturation, and apoptosis.

3. The device according to claim 1, wherein the predetermined target component is an endothelial progenitor cell, and the signal agent up regulates the proliferation and maturation of the endothelial progenitor cell to increase the rate of endothelialization and reduce the time for inflammation and thrombosis.

4. The device. according to claim 3, wherein the signal agent is an endothelial progenitor cell specific L-PDMP.

5. The device according to claim 1, wherein the signal agent is arranged in a first conformation of a single arm structure to function independently of the capture agent.

6. The device according to claim 5, wherein the signal agent down regulates the cell function of a cell to reduce proliferation or up regulate the apoptosis of undesirable cells adsorbed on the surface of the membrane.

7. The device according to claim 6, wherein the signal agent is SMC-specific D-PDMP.

8. The device according to claim 1, further comprising at least one signal agent permanently attached to the vessel wall surface of the membrane to signal a predetermined target component from the vessel wall in contact with the membrane to up regulate or down regulate a cell function to enhance healing of the vessel wall and incorporation of the device into the vessel wall.

9. The device according to claim 8, wherein the cells are any one from the group consisting of:

fibroblast cells and smooth muscle cells.

10. The device according to claim 8, wherein the cell function is any one from the group consisting of:

production of protein chains and proliferation.

11. The device according to claim 8, further comprising at least one capture agent permanently attached to the vessel wall surface of the membrane to capture the predetermined target component from the vessel wall in contact with the membrane.

12. The device according to claim 11, wherein the cell function is any one from the group consisting of:

proliferation, migration, maturation and apoptosis.

13. The device according to claim 1, wherein the signal agent is an anti-inflammatory agent and the cell function is to reduce the recruitment and infiltration of white blood cells.

14. The device according to claim 1, wherein the signal agent enhances endothelial cell alignment and proliferation of endothelial cells to the membrane.

15. The device according to claim 14, wherein the capture agent and signal agent increase the rate of endothelialization to decrease the time for the reaction of thrombosis and restenosis to occur after the mechanically expandable device is expanded to the second position.

16. The device according to claim 1, wherein the capture agent is arranged in a first conformation of a single arm structure made up of an organic linker anchored to the membrane.

17. The device according to claim 1, wherein the capture and signal agents are arranged in a second conformation of a branched structure made up of an organic linker anchored to the membrane.

18. The device according to claim 1, wherein the membrane is made from either a biostable or a biodegradable material.

19. The device according to claim 1, wherein the membrane is solid or permeable.

20. The device according to claim 1, wherein the capture and signal agents are any one from the group consisting of:

enzyme regulators tagged with antibodies or peptides, L-PDMP, peptides, antibodies, naturally occurring molecules, and synthetic molecules.

21. The device according to claim 1, wherein the membrane includes an intermediate layer to mimic the basal lamina such that endothelial cells form a strong bond with the membrane.

22. The device according to claim 1, wherein the membrane is secured to the entire circumferential surface of the mechanically expandable device.

23. The device according to claim 1, wherein the bodily vessel is any one from the group consisting of:

intracranial bodily vessel, bodily vessel suffering from a hemorrhagic, ischemic or vascular disease, bodily vessel with damaged vessel walls, and bodily vessel less than 4 mm in diameter.

24. An endovascular device for treatment of a bodily vessel of a patient at a surgical site, the endovascular device comprising:

a mechanically expandable device expandable from a first position to a second position, said mechanically expandable device is expanded radially outwardly to the second position such that the circumferential surface of said mechanically expandable device engages with the inner surface of the vessel so as to maintain a fluid pathway through said vessel; and

a membrane secured to a portion of the circumferential surface of said mechanically expandable device;

wherein at least one capture agent is permanently attached to the vessel wall surface of the membrane to enhance healing of the vessel wall from injury caused after the mechanically expandable device is expanded to the second position and to enhance healing of the vessel wall and incorporation of the device into the vessel wall.

25. The device according to claim 24, wherein the capture agent enables proliferation of vessel wall components to enhance the healing of the weakened or breached portion of the vessel wall.

26. The device according to claim 24, wherein the capture agent encourages proliferation and bridging of vessel wall components across a weakened, torn or breached portion of the vessel wall to enhance healing and encasement of the device at a portion of the device in contact with the vessel wall.

27. The device according to claim 24, wherein the capture agent is arranged in a first conformation of a single arm structure made up of an organic linker anchored to the membrane.

28. The device according to claim 24, wherein the capture agent is arranged in a second conformation of a branched structure made up of an organic linker anchored to the membrane.

29. An endovascular device for treatment of a bodily vessel of a patient at a surgical site, the endovascular device comprising:

a mechanically expandable device expandable from a first position to a second position, said mechanically expandable device is expanded radially outwardly to the second position such that the circumferential surface of said mechanically expandable device engages with the inner surface of the vessel so as to maintain a fluid pathway through said vessel; and

wherein at least one capture agent is permanently attached to the lumenal side of the device to capture a predetermined target component from blood passing through the fluid pathway, and at least one signal agent is permanently attached to the lumenal side of the device to signal the captured target component to up regulate or down regulate a cell function of the captured target component to enhance endothelialization and healing; and

a third agent is permanently attached to the vessel wall side of the device to enhance healing of the vessel wall from injury caused after the mechanically expandable device is expanded to the second position.

30. The device according to claim 29, further comprising a membrane secured to a portion of the circumferential surface or entire circumferential surface of said mechanically expandable device;

the first, second and third agents being permanently attached to the membrane.

31. The device according to claim 29, wherein the third agent is arranged in a first conformation of a single arm structure made up of an organic linker anchored to the membrane.

32. The device according to claim 29, wherein the third agent is arranged in a second conformation of a branched structure made up of an organic linker anchored to the membrane.

33. The device according to claim 29, wherein the third agent enables proliferation of vessel wall components to enhance the healing of the weakened or breached portion of the vessel wall.