MOUSE/HUMAN CHIMERIC ANTI-PHENCYCLIDINE ANTIBODY AND USES THEREOF
First Claim
1. A method of treating arylcyclohexylamine drug abuse, the method comprising administering a chimeric mouse/human monoclonal antibody specific for phencyclidine or phencyclidine-like drugs to a subject, wherein administration of the chimeric antibody modulates the adverse effects of arylcyclohexylamine drug abuse.
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Accused Products
Abstract
The present invention provides a chimeric mouse/human antibody (ch-mAb6B5) for treatment of abuse and toxicity of the arylcyclohexylamines class of drugs (i.e., phencyclidine- or PCP-like drugs). This antibody comprises light and heavy chain PCP binding regions of mouse mAb6B5, coupled to the light and heavy chain constant regions of a human kappa IgG2 or IgG4 isoform. Also provided are the DNA and amino acid sequences of the chimeric light and heavy chain of this antibody. Further provided are data that demonstrate that the new chimeric antibody retains the high affinity and specificity of a previously generated mouse anti-PCP monoclonal antibody (mAb6B5) yet being minimally immunogenic since it has human immunoglobulin constant region. This new medication would allow safe and effective treatment of PCP drug overdose, decrease mortality, and reduce harmful effects due to excessive and prolonged PCP drug use.
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20 Claims
- 1. A method of treating arylcyclohexylamine drug abuse, the method comprising administering a chimeric mouse/human monoclonal antibody specific for phencyclidine or phencyclidine-like drugs to a subject, wherein administration of the chimeric antibody modulates the adverse effects of arylcyclohexylamine drug abuse.
- 9. A method of treating phencyclidine drug abuse, the method comprising administering a pharmaceutically effective amount of a chimeric mouse/human monoclonal antibody specific for phencyclidine to a subject, wherein administration of the chimeric antibody modulates the adverse effects of phencyclidine drug abuse.
- 16. A method of decreasing the concentration of phencyclidine in the brain of a subject, the method comprising administering a pharmaceutically effective amount of a chimeric mouse/human monoclonal antibody specific for phencyclidine to the subject.
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