Photoelectrochemical synthesis of high density combinatorial polymer arrays
First Claim
1. A method for photoelectrochemical placement of a material at a specific location on a substrate, comprising the steps of:
- providing a substrate having at the substrate surface at least one photoelectrode that is proximate to at least one molecule bearing at least one chemical functional group;
providing a reagent-generating chemistry co-localized with the chemical functional group and capable of generating reagents when subjected to a potential above a threshold; and
applying an input potential to the photoelectrode to create a patterned substrate, the input potential exceeding the threshold in the presence of light and not exceeding the threshold in the absence of light.
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Abstract
In a method for creating polymer arrays through photoelectrochemically modulated acid/base/radical generation for combinatorial synthesis, electrochemical synthesis is guided by a spatially modulated light source striking a semiconductor in an electrolyte solution. A substrate having at its surface at least one photoelectrode that is proximate to at least one molecule bearing at least one chemical functional group is provided, along with a reagent-generating chemistry co-localized with the chemical functional group and capable of generating reagents when subjected to a potential above a threshold. An input potential is then applied to the photoelectrode that exceeds the threshold in the presence of light and that does not exceed the threshold in the absence of light, causing the transfer of electrons to or from the substrate, and creating a patterned substrate. The process is repeated until a polymer array of desired size is created.
98 Citations
35 Claims
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1. A method for photoelectrochemical placement of a material at a specific location on a substrate, comprising the steps of:
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providing a substrate having at the substrate surface at least one photoelectrode that is proximate to at least one molecule bearing at least one chemical functional group;
providing a reagent-generating chemistry co-localized with the chemical functional group and capable of generating reagents when subjected to a potential above a threshold; and
applying an input potential to the photoelectrode to create a patterned substrate, the input potential exceeding the threshold in the presence of light and not exceeding the threshold in the absence of light. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
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29. A method for photoelectrochemical synthesis of a polymer array, comprising the steps of:
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(a) providing a substrate having at the substrate surface at least one photoelectrode that is proximate to at least one molecule bearing at least one chemical functional group;
(b) providing a reagent-generating chemistry co-localized with the chemical functional group capable of generating reagents when subjected to a potential above a threshold;
(c) applying an input potential to the photoelectrode to create a patterned substrate, the input potential exceeding the threshold in the presence of light and not exceeding the threshold in the absence of light; and
(d) repeating steps (a) to (c) until a polymer array of desired size is synthesized. - View Dependent Claims (30, 31, 32)
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33. A method for photoelectrochemical placement of a material at a specific location on a substrate, comprising the steps of:
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providing a substrate having at the substrate surface at least one photoelectrode that is proximate to at least one molecule bearing at least one chemical functional group that can be cleaved;
providing a cleaving reagent-generating chemistry co-localized with the chemical functional group that is capable of generating cleaving reagents when subjected to a potential above a threshold; and
applying an input potential to the photoelectrode to create a patterned substrate, the input potential exceeding the threshold in the presence of light and not exceeding the threshold in the absence of light. - View Dependent Claims (34, 35)
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Specification