ANTIMICROBIAL PLASTICS COMPOSITION WITH LOW ELUTION RATE AND WITH LONG PERIOD OF ACTIVITY

• US 20070208104A1
• Filed: 10/06/2006
• Published: 09/06/2007
• Est. Priority Date: 10/06/2005
• Status: Abandoned Application

• Current Assignee: Bayer Innovation GmbH (Bayer AG)
• Original Assignee: Bayer Innovation GmbH (Bayer AG)
• Inventors: Pudleiner, Heinz, Hyner, Joachim
• Application Number:
  US11/539,279
• Publication Number:
  US 20070208104A1
• Time in Patent Office: Days
• US Class Current: 523/122
• CPC Class Codes: A61L 2300/00 Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: C08K 5/0058 Biocides; macromolecular substances as carriers for biocide material A01N25/10
• CPC Class Codes: C08K 5/3432 Six-membered rings
• CPC Class Codes: C08L 75/08 from polyethers

Abstract

The present invention relates to antimicrobial plastics compositions comprising a thermoplastic elastomer (TPE), particularly thermoplastic polyurethanes, and of at least one antimicrobial active ingredient from the group of the bis(4-amino-1-pyridinium)alkanes, specifically octinidine. The present invention also relates to the preparation of these compositions, and also to the use of these plastics compositions for catheters and other applications including medical-technology products.

Claims

1. A composition comprising a thermoplastic elastomer and at least one active ingredient selected from the group consisting of bis(4-(substituted amino)-1-pyridinium)alkanes.

2. A composition according to claim 1, wherein the thermoplastic elastomer is selected from the group consisting of copolyester, polyether block amides and thermoplastic polyurethanes.

3. A composition according to claim 1, wherein the active ingredient is selected from the group consisting of compounds of substances of formulae (I) and (II)

where

Y independent in each case is an alkylene group having from 4 to 18 carbon atoms,

R independent in each case is C₆-C₁₈-alkyl, C₅-C₇-cycloalkyl or halogen-atom-substituted phenyl and

A independent in each case is two monovalent anions or a divalent anion.

4. A composition according to claim 1, wherein the concentration of the active ingredient in said composition is sufficient to suppress or significantly reduce, over a prolonged period, colonization by undesired microbes.

5. A composition according to claim 1, wherein the concentration of the active ingredient is from 0.01 to 5 percent by weight, based on the weight of active ingredient and thermoplastic elastomer.

6. A composition according to claim 1, comprising thermoplastic polyurethane and octenidine dihydrochloride.

7. A process for preparing of a plastics according to claim 1, comprising extruding a melt comprising said active ingredient and said thermoplastic elastomer.

8. A molding comprising a composition according to claim 1.

9. A composition of claim 4, wherein said prolonged period is at best about two weeks, and said undesired microbes comprise bacteria, viruses and/or fungi.

10. A composition of claim 1, wherein said active ingredient remains in said composition at an amount of from 93.3%-99.8% over 360 hours.

11. A composition of claim 1, wherein said composition does not produce a biofilm when exposed to bacteria, viruses and/or fungi.

12. A composition of claim 6, wherein said active ingredient remains in said composition at an amount of from 93.3%-99.8% over 360 hours.

13. A composition of claim 6, wherein said composition does not produce a biofilm when exposed to bacteria, viruses and/or fungi.

14. A composition according to claim 2, wherein the concentration of the active ingredient in said composition is sufficient to suppress or significantly reduce, over a prolonged period, colonization by undesired microbes.

15. A composition of claim 2, wherein said prolonged period is at best about two weeks, and said undesired microbes comprise bacteria, viruses and/or fungi.

16. A composition of claim 3, wherein said prolonged period is at best about two weeks, and said undesired microbes comprise bacteria, viruses and/or fungi.

17. A composition of claim 6, wherein said prolonged period is at best about two weeks, and said undesired microbes comprise bacteria, viruses and/or fungi.

18. A process for preparing of a plastics according to claim 6, comprising extruding a melt comprising said active ingredient and thermoplastic elastomer.

19. A medical product comprising a composition of claim 6.

20. A medical product of claim 19 comprising a catheter hose, foil, connector, fiber and/or non-woven.

21. A medical product of claim 19, wherein said product releases less than about 5% of said active ingredient over a period of 15 days.