Three diode optical bridge system
First Claim
1. A method of generating a beam of electromagnetic radiation for the non-invasive measurement of a concentration of a target analyte in a fluid within a sample matrix, the method comprising:
- directing a combined beam of electromagnetic radiation at the sample, the combined beam including at least two repetitive periods of radiation having different wavelengths, the target analyte having different absorption coefficients for the different wavelengths, and where the radiation during at least one period of radiation consists of a mixture of at least two radiations of different wavelengths, having an effective wavelength equal to the intensity-weighted mean of the two component wavelengths.
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Accused Products
Abstract
An improved method for non-invasively measuring a concentration of a target analyte dissolved in a fluid flowing through a sample is presented. It includes directing a probe beam of electromagnetic radiation, consisting of time multiplexed components of different wavelengths, where at least one of the time-multiplexed components consists of two different simultaneous wavelengths, whose intensity relation defines the effective wavelength of their combination, through the sample and measuring the difference of the absorption of the radiation of the time-multiplexed components at different sample states. During sample state changes, the amount of fluid containing the target analyte within the sample is changing, which varies the total amount of target analyte in the sample, as well as the absorption properties of the sample. The sample states are produced, for instance, by compressing and uncompressing the tissue sample. The accuracy of the presented method is enhanced by including continuous estimation of the amount of the fluid containing the target analyte within the sample, and measurement of the variations of the absorption at a wavelength at which the target analyte absorbs significantly. The method is particularly useful in measuring the concentration of a target analyte, such as glucose, in tissue containing blood. An apparatus for performing this method also is disclosed.
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Citations
9 Claims
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1. A method of generating a beam of electromagnetic radiation for the non-invasive measurement of a concentration of a target analyte in a fluid within a sample matrix, the method comprising:
directing a combined beam of electromagnetic radiation at the sample, the combined beam including at least two repetitive periods of radiation having different wavelengths, the target analyte having different absorption coefficients for the different wavelengths, and where the radiation during at least one period of radiation consists of a mixture of at least two radiations of different wavelengths, having an effective wavelength equal to the intensity-weighted mean of the two component wavelengths. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A system for the non-invasive measurement of a concentration of a target analyte in a fluid within a sample matrix, comprising:
a source of electromagnetic radiation that directs a combined beam of electromagnetic radiation at the sample, the combined beam including at least two repetitive periods of radiation having different wavelengths, the target analyte having different absorption coefficients for the different wavelengths, and where the radiation during at least one period of radiation consists of a mixture of at least two radiations of different wavelengths, having an effective wavelength equal to the intensity-weighted mean of the two component wavelengths. - View Dependent Claims (9)
Specification