METHODS FOR QUANTIFYING THE RISK OF CARDIAC DEATH USING EXERCISE INDUCED HEART RATE VARIABILITY METRICS
First Claim
1. A method for assessing cardiac risks in a specific patient based on heart rate variability, comprising:
- providing heart activity data of a specific patient including a windowed time series related to heart rate variability during a heart rate test;
determining a frequency domain value based on at least one of energy values of frequency bands and spectral slope(s) across selected frequency ranges of the heart activity data in the windowed time series; and
assessing the risk of a cardiac event based on the frequency domain value.
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Abstract
Methods and apparatus for assessing cardiac risks in a specific patient. One embodiment of a method in accordance with the invention comprises providing heart rate activity of a specific patient including a windowed time series relating to heart rate variability during a heart rate test. This method further includes determining a frequency domain value based on energy values of frequency bands of the heart rate variability in the windowed time series, and/or determining an aggregate power for a frequency band of the windowed time series. This method further includes assessing the risk of a cardiac event based on the frequency value and/or the aggregate power.
170 Citations
41 Claims
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1. A method for assessing cardiac risks in a specific patient based on heart rate variability, comprising:
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providing heart activity data of a specific patient including a windowed time series related to heart rate variability during a heart rate test;
determining a frequency domain value based on at least one of energy values of frequency bands and spectral slope(s) across selected frequency ranges of the heart activity data in the windowed time series; and
assessing the risk of a cardiac event based on the frequency domain value. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. A method for assessing cardiac risks in a specific patent based on heart rate variability, comprising:
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providing heart activity data of a specific patient including a windowed time series related to heart rate variability during a heart rate test, the windowed time series including ecotopic beats;
determining an aggregate power for a frequency band of the windowed time series; and
assessing the risk of a cardiac event based on the aggregate power. - View Dependent Claims (18, 19, 20, 21, 22, 23, 24, 25)
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26. A method for assessing cardiac risks in a specific patient based on heart rate variability, comprising:
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providing heart activity data of a specific patient including a windowed time series related to heart rate variability during a heart rate test;
determining a frequency domain value based on energy values of frequency bands of the heart rate variability in the windowed time series;
determining an aggregate power for a frequency band of the windowed time series; and
assessing the risk of a cardiac event based on the frequency value and the aggregate power. - View Dependent Claims (27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38)
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39. An apparatus for assessing cardiac risks in a specific patient based on heart rate variability, comprising:
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at least one sensor configured to obtain cardiac signals from a specific patient; and
a computer configured to receive the cardiac signals from the sensor, and the computer including a computer operable medium having instructions that cause the computer to (a) provide heart activity data of a specific patient including a windowed time series related to heart rate variability during a heart rate test, (b) determine an aggregate power for a frequency band of the windowed time series, and (c) assess the risk of a cardiac event based on the aggregate power.
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40. An apparatus for assessing cardiac risks in a specific patient based on heart rate variability, comprising:
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at least one sensor configured to obtain cardiac signals from a specific patient; and
a computer configured to receive the cardiac signals from the sensor, and the computer including a computer operable medium having instructions that cause the computer to (a) provide heart activity data of the specific patient including a windowed time series related to heart rate variability during a heart rate test, (b) determine a frequency domain value based on at least one of energy values of frequency bands and spectral slope(s) across selected frequency ranges of the heart activity data in the windowed time series, and (c) assess the risk of a cardiac event based on the frequency domain value.
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41. The apparatus of claim 41 wherein the heart activity data comprises an instantaneous heart rate sequence from an ECG waveform obtained during an exercise period of increasing heart rate and a recovery period of decreasing heart rate, and the instructions cause the computer to provide a uniform sample series of the instantaneous heart rate sequence, and reduce the uniform sample series by filtering and/or detrending via fitting a polynomial function to the heart activity data across a selected time window to obtain a heart rate variability waveform associated with variances in the heart rate between beats in a desired frequency band.
Specification