LIQUID DISPENSING APPARATUS AND METHODS

• US 20070209659A1
• Filed: 02/12/2007
• Published: 09/13/2007
• Est. Priority Date: 04/05/1995
• Status: Active Grant

• Current Assignee: Novartis Ag
• Original Assignee: Aerogen, Inc. (Nektar Therapeutics)
• Inventors: Ivri, Yehuda, Wu, Cheng
• Granted Patent: US 8,561,604 B2
• Time in Patent Office: Days
• US Class Current: 128/200.140
• CPC Class Codes: A61M 11/005 using ultrasonics spraying or atomising liquids using ultrasonic vibrations in general B05B17/06
• CPC Class Codes: A61M 15/0085 using ultrasonics spraying or atomising liquids using ultrasonic vibrations in general B05B17/06
• CPC Class Codes: A61M 15/009 using medicine packages with incorporated spraying means, e.g. aerosol cans pocket atomiser of the injector type A61M11/08
• CPC Class Codes: A61M 2016/0021 with a proportional output signal, e.g. from a thermistor
• CPC Class Codes: A61M 2016/0039 in the inspiratory circuit

Abstract

The invention provides methods and apparatus for nebulizing liquids. In one exemplary embodiment, an apparatus is provided which comprises a thin shell member having a front surface, a rear surface, and a plurality of apertures extending therebetween. The apertures are tapered to narrow from the rear surface to the front surface. A liquid supplier is further provided which delivers a predetermined unit volume of liquid to the rear surface. A vibrator vibrates the thin shell member to eject liquid droplets from the front surface of the thin shell member.

Claims

1-47. -47. (canceled)

48. A method for aerosolizing a liquid, the method comprising:

providing an aerosolization device comprising an aerosol generator, an inhalation sensor, and control circuitry, wherein the aerosol generator comprises a plate having a plurality of apertures and a vibratable element that is mechanically linked to the plate, wherein the vibratable element is configured to vibrate the plate, and wherein the plate is non-planar in geometry;

sensing a user inhalation with the sensor and transmitting an electrical signal to the control circuitry;

sending a signal from the control circuitry to vibrate the vibratable element when the inhalation reaches a threshold amount.

49. A method as in claim 48, further comprising stopping vibration of the vibratable element when the inhalation falls below the threshold amount.

50. A method as in claim 48, wherein the inhalation is sensed by sensing air moving through at least a portion of the aerosolization device.

51. A method as in claim 48, wherein the vibratable element comprises a piezoelectric transducer, and further comprising sending an electrical signal from the control circuitry to the piezoelectric transducer to vibrate the plate.

52. An aerosolization device comprising:

a housing;

an aerosol generator operably coupled to the housing, wherein the aerosol generator comprises a plate having a plurality of apertures and a vibratable element that is mechanically linked to the plate, wherein the aerosol generator is adapted to aerosolize a liquid for delivery to a user, and wherein the plate is non-planar in geometry;

an inhalation sensor that is configured to sense when the user inhales and to produce an electrical signal that is based on the sensed inhalation;

control circuitry that is configured to actuate the aerosol generator when the electrical signal indicates that the inhalation has reached a threshold amount.

53. A device as in claim 52, wherein the control circuitry is further control circuitry that is configured to actuate the aerosol generator when configured to stop actuation of the aerosol generator when the electrical signal indicates that the inhalation has fallen below the threshold amount.

54. A device as in claim 52, wherein the inhalation sensor is configured to sense air moving through at least a portion of the aerosolization device.

55. A device as in claim 52, wherein the vibratable element comprises a piezoelectric transducer.