METHODS AND DEVICES FOR THE DETECTION AND MEASUREMENT OF FREE METALS IN FLUIDS AND METHODS FOR DIAGNOSING METAL-RELATED DISEASES AND FOR DETERMINING PHARMACOLOGIC DOSING REGIMENS
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1. A detection method or a method for a point of care diagnostic assay which comprises detecting non-covalently bound copper (free copper) concentrations in a fluid.
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Abstract
A detection method or a method for a point of care diagnostic assay which comprises detecting non-covalently bound copper (free copper) concentrations in a fluid.
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34 Claims
- 1. A detection method or a method for a point of care diagnostic assay which comprises detecting non-covalently bound copper (free copper) concentrations in a fluid.
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6. A method of diagnosing Alzheimer'"'"'s disease, Parkinson'"'"'s disease, schizophrenia, Wilson'"'"'s disease or other copper metabolic disorder in an individual, which comprises directly measuring a free copper pool in a fluid sample of that individual.
- 7. An assay device for detection of free or loosely bound copper comprising an enzyme capable of forming a holo-enzyme in the presence of copper.
- 9. An assay device for detection of free or loosely bound copper, which comprises an enzyme which uses copper as a co-factor.
- 12. An assay device for detection of copper, wherein enzyme activity is measured using a spectrophotometric or electrochemical system.
- 27. A device that measures the state of copper in blood as a gradient of free to loosely to tightly bound copper is measured, wherein free copper in blood is based on a measurement of enzyme activity as an initial rate and not at equilibrium.
- 31. An assay device for detection of free or loosely bound copper comprising a copper-dependent enzyme attached to a bead.
- 33. A method for measuring the concentration of copper in serum or blood by reconstitution of an enzyme attached to a bead from an apo-form to a holo-form.
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