Cell canaries for biochemical pathogen detection
First Claim
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1. A device for detecting at least one pathogen, comprising:
- at least one cell that produces a signal upon contact with the pathogen;
at least one cell clinic on a surface of a chip for containing the cell; and
an on-chip means for detecting the signal, wherein the cell specifically produces a signal when exposed to the pathogen, and detecting the signal correlates with the presence of the pathogen.
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Abstract
Methods and compositions for the reliable detection of pathogens are presented. The invention uses cells as novel pathogen detection agents, exploiting pathogen-specific pathways and apoptosis.
204 Citations
31 Claims
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1. A device for detecting at least one pathogen, comprising:
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at least one cell that produces a signal upon contact with the pathogen;
at least one cell clinic on a surface of a chip for containing the cell; and
an on-chip means for detecting the signal, wherein the cell specifically produces a signal when exposed to the pathogen, and detecting the signal correlates with the presence of the pathogen. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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23. A device for detecting pathogens, comprising:
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a plurality of cells-that produce at least one signal upon contact with a pathogen;
a cell clinic comprising a plurality of vials on a surface of a chip for containing the cells, each vial containing at least one cell responsive to a specific pathogen; and
a means for detecting responses of the cells to the pathogens, wherein the cells specifically produce at least one signal to the pathogens, and detecting the signal correlates with the presence of at least one pathogen. - View Dependent Claims (24, 25, 26, 27, 28, 29)
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30. A method of analyzing a sample, comprising:
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introducing the sample into a cell canary, the cell canary comprising a cell that produces a specific signal in response to a pathogen; and
assaying the cell for the signal, wherein detecting the signal correlates with the presence of the pathogen.
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31. The method of claim 30, wherein the signal comprises fluorescence.
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31-1. A method of making a device for detecting a pathogen, comprising:
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fabricating on a chip at least one means for detecting a signal from at least one cell having a specific signal in response to a pathogen;
fabricating at least one cell clinic on a surface of the chip for containing the cell; and
loading the cell into the cell clinic.
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Specification