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Enriched Pancreatic Stem Cell and Progenitor Cell Populations, and Methods for Identifying, Isolating and Enriching for Such Populations

  • US 20070212732A1
  • Filed: 08/27/2004
  • Published: 09/13/2007
  • Est. Priority Date: 08/27/2003
  • Status: Abandoned Application
First Claim
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1. A method of producing a population from pancreatic tissue enriched for human pancreatic stem cells, progenitors, or a combination thereof, comprising:

  • a) contacting pancreatic tissue, pancreatic cells, pancreatic-derived cells, or primary gastrointestinal tissue or gastrointestinal-derived cells with a monoclonal antibody that binds CD133 or CD49f; and

    b) selecting said pancreatic tissue, pancreatic cells, pancreatic-derived cells, or primary gastrointestinal tissue or gastrointestinal-derived cells that bind to the monoclonal antibody;

    wherein the selected cells are enriched for human pancreatic stem cells, progenitors, or a combination thereof.

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