Substituted pyrrolines as kinase inhibitors
First Claim
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1. A method for treating or ameliorating a kinase mediated disorder comprising administering to a subject in need thereof a therapeutically effective amount of a compound of Formula (I):
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Abstract
The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
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23 Claims
- 1. A method for treating or ameliorating a kinase mediated disorder comprising administering to a subject in need thereof a therapeutically effective amount of a compound of Formula (I):
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3. The method of claim 3 wherein the kinase is selected from protein kinase C α
- , protein kinase C β
-II, protein kinase C γ
or glycogen synthase kinase-3β
.
- , protein kinase C β
- 19. A method of treating or ameliorating a disorder selected from diabetes-associated disorders, dermatological disorders, oncological disorders or central nervous system disorders comprising administering to a subject in need of treatment a therapeutically effective amount of a compound of Formula (I):
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