DUAL ELECTRODE SYSTEM FOR A CONTINUOUS ANALYTE SENSOR
First Claim
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1. An analyte sensor configured for measuring an analyte in a host, the sensor comprising:
- a first working electrode disposed beneath an active enzymatic portion of a sensor membrane; and
a second working electrode disposed beneath an inactive-enzymatic portion of a sensor membrane or a non-enzymatic portion of a sensor membrane, wherein the sensor membrane comprises an interference domain located over the first working electrode and the second working electrode, wherein the interference domain is configured to substantially block flow of at least one interfering species.
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Abstract
Disclosed herein are systems and methods for a continuous analyte sensor, such as a continuous glucose sensor. One such system utilizes first and second working electrodes to measure analyte or non-analyte related signal, both of which electrode include an interference domain.
532 Citations
38 Claims
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1. An analyte sensor configured for measuring an analyte in a host, the sensor comprising:
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a first working electrode disposed beneath an active enzymatic portion of a sensor membrane; and
a second working electrode disposed beneath an inactive-enzymatic portion of a sensor membrane or a non-enzymatic portion of a sensor membrane, wherein the sensor membrane comprises an interference domain located over the first working electrode and the second working electrode, wherein the interference domain is configured to substantially block flow of at least one interfering species. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30)
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31. An analyte sensor configured for measuring glucose in a host, the sensor comprising:
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a first working electrode configured to generate a first signal indicative of glucose and non-glucose related electroactive compounds having a first oxidation potential; and
a second working electrode configured to generate a second signal indicative of non-glucose related electroactive compounds having the first oxidation potential; and
electronics configured to process the first signal and the second signal, wherein the sensor further comprises at least two mechanisms configured to substantially block or substantially eliminate noise in the sensor signal, the mechanisms comprising a first mechanism disposed on the sensor and configured to reduce or substantially block interferants from reaching the first working electrode and the second working electrode, and a second mechanism in the electronics comprising programming configured to process the first signal to substantially eliminate the signal associated with the non-glucose related electroactive compounds therefrom. - View Dependent Claims (32, 33, 34, 35, 36, 37)
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38. A method for providing a substantially noise-free signal for a glucose sensor implanted in a host, the method comprising:
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implanting a glucose sensor in a host, the glucose sensor comprising;
a first working electrode disposed beneath an active enzymatic portion of a sensor membrane;
and a second working electrode disposed beneath an inactive-enzymatic or a non-enzymatic portion of a sensor membrane, wherein the sensor is configured to substantially block one or more interferants from reaching the first working electrode and the second working electrode;
generating a first signal indicative of glucose and non-glucose related electroactive compounds having a first oxidation potential;
generating a second signal indicative of non-glucose related electroactive compounds having the first oxidation potential; and
processing the first signal to substantially eliminate the signal associated with the non-glucose related electroactive compounds therefrom.
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Specification