Baseline correction in systems for detecting ischemia

• US 20070213626A1
• Filed: 09/08/2006
• Published: 09/13/2007
• Est. Priority Date: 03/10/2006
• Status: Abandoned Application

• Current Assignee: Angel Medical Systems, Inc.
• Original Assignee: Angel Medical Systems, Inc.
• Inventors: John, Michael Sasha, Hopenfeld, Bruce, Fischell, David R.
• Application Number:
  US11/517,382
• Publication Number:
  US 20070213626A1
• Time in Patent Office: Days
• US Class Current: 600/509
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/30 Input circuits therefor
• CPC Class Codes: A61B 5/308 for electrocardiography [ECG]
• CPC Class Codes: A61B 5/349 Detecting specific parameters of the electrocardiograph cycle
• CPC Class Codes: A61B 5/358 Detecting ST segments
• CPC Class Codes: A61N 1/3704 Circuits specially adapted therefor, e.g. for sensitivity control

Abstract

The present invention is a system that utilizes different filtering techniques to provide accurate detection of changes in the ST segment of an electrogram as detected by an implanted cardiosaver system, which ST segment changes are indicative of coronary ischemia. To accurately detect changes in the ST segment of the electrogram, the cardiosaver system partitions electrograms into different partition series, preferably including the QRS and ST segments, respectively. These partition series are then passed through different analog or digital high pass filters. An alternate embodiment involves low pass filtering the electrogram and then subtracting off the filtered signal, which represents baseline wander, from the electrogram. The system also includes both implanted and external portions that provide a patient alarm if coronary ischemia is sensed.

Claims

1. An implanted system for the detection of coronary ischemia in a human patient, the system including:

(a) at least two electrodes for obtaining an electrical signal from the patient'"'"'s heart, the electrical signal being an electrogram that has a signal voltage corresponding to the heart'"'"'s electrical activity over a plurality of heartbeats; and

(b) an electrical signal processor configured to remove at least a portion of the QRS complex corresponding to the plurality of heartbeats, thereby deriving an extracted signal, the processor further configured to at least partially correct for baseline wander in the extracted signal, thereby generating a processed signal, the processor further configured to detect a feature of the processed signal that may indicate the presence of coronary ischemia.

2. The system of claim 1 wherein the extracted signal comprises a plurality of ST segments.

3. The system of claim 2 wherein the extracted signal further comprises a plurality of PQ segments, and the presence of coronary ischemia is indicated by the difference between ST segment values and corresponding PQ segment values.

4. The system of claim 1, further including a high pass filter configured to filter the extracted signal, thereby at least partially correcting for baseline wander.

5. The system of claim 4 wherein the high pass filter provides more than 3 dB of attenuation at a frequency greater than 1 Hz compared to the attenuation provided at 3 Hz.

6. An implanted system for the detection of coronary ischemia in a human patient, the system including:

(a) at least two electrodes for obtaining an electrical signal from the patient'"'"'s heart, the electrical signal being an electrogram that has a signal voltage corresponding to the heart'"'"'s electrical activity over a plurality of heartbeats;

(b) an electrical signal processor configured to partition the electrogram into first and second partition series that include first and second electrocardiogram segments, respectively;

(c) first and second filters configured to filter the first and second partition series, respectively, thereby generating first and second filtered signals, wherein the first filter has a substantially different frequency response than the second filter; and

(d) wherein the electrical signal processor is configured to analyze features of the first and second filtered signals to detect the presence of coronary ischemia.

7. The system of claim 6 wherein the first segment is the ST segment and the second segment is the QRS complex.

8. The system of claim 7 wherein the first partition series further includes the PQ segment.

9. The system of claim 7 wherein the first partition series further includes the T wave.

10. The system of claim 7 wherein the presence of coronary ischemia is detected by analyzing the amplitude of ST segments normalized to the amplitude of corresponding QRS complexes.

11. The system of claim 6 wherein the first filter provides more than 3 dB of attenuation at a frequency greater than 1 Hz compared to the attenuation provided at 3 Hz.

12. The system of claim 6 wherein the first partition series comprises a plurality of individual partitions that are linked together with windowing functions.

13. The system of claim 6 wherein the first partition series comprises a plurality of individual partitions that are linked together by assigning a common voltage to the first point in each individual partition.

14. An implanted system for the detection of coronary ischemia in a human patient, the system including:

(a) at least two electrodes for obtaining an electrical signal from the patient'"'"'s heart, the electrical signal being an electrogram that has a signal voltage corresponding to the heart'"'"'s electrical activity over a plurality of heartbeats;

(b) a high pass filter that provides more than 3 dB of attenuation at a frequency greater than 1 Hz compared to the attenuation provided at 3 Hz, the filter coupled to receive the electrogram and to generate a filtered signal; and

(c) an electrical signal processor configured to detect a feature of the filtered signal that may indicate the presence of coronary ischemia.

15. The system of claim 14 wherein the electrical signal processor is further configured to extract ST segments from the electrogram, thereby deriving an extracted signal comprising ST segments, and wherein the filter is configured to filter the extracted signal.

16. The system of claim 15 wherein the extracted signal further comprises PQ segments.

17. An implanted system for the detection of coronary ischemia in a human patient, the system including:

(a) at least two electrodes for obtaining an electrical signal from the patient'"'"'s heart, the electrical signal being an electrogram that has a signal voltage corresponding to the heart'"'"'s electrical activity over a plurality of heartbeats;

(b) a low pass filter that attenuates most frequencies above 1 Hz more than it attenuates most frequencies below 1 Hz, the filter coupled to filter the electrogram, thereby generating a filtered signal; and

(c) an electrical signal processor configured to subtract the filtered signal from the electrogram, thereby deriving a corrected signal, the signal processor further configured to detect a feature of the corrected signal that may indicate the presence of coronary ischemia.

18. The system of claim 17 wherein the feature of the corrected signal pertains to ST segment voltage.

19. A method for detecting coronary ischemia in a human patient, the system including the steps of:

(a) receiving an electrical signal from at least two electrodes for obtaining an electrical signal from the patient'"'"'s heart, the electrical signal characterized by a signal voltage corresponding to the heart'"'"'s electrical activity over a plurality of heartbeats;

(b) selecting filter characteristics as a function of the frequency of the patient'"'"'s heart beat;

(c) filtering the electrical signal according to the selected filter characteristics, thereby deriving a filtered signal; and

(d) detecting a feature of the corrected signal that may indicate the presence of coronary ischemia.

20. The system of claim 19 wherein the feature of the corrected signal pertains to ST segment voltage.