SYSTEM AND METHOD FOR REMOTE BASED CONTROL OF AN IONTOPHORESIS DEVICE

• US 20070213652A1
• Filed: 12/28/2006
• Published: 09/13/2007
• Est. Priority Date: 12/30/2005
• Status: Abandoned Application

• Current Assignee: TTI Ellebeau, Inc. (Ease Asset Management Ltd.)
• Original Assignee: Transcutaneous Technologies, Inc.
• Inventors: Carter, Darrick
• Application Number:
  US11/617,609
• Publication Number:
  US 20070213652A1
• Time in Patent Office: Days
• US Class Current: 604/20
• CPC Class Codes: A61N 1/0436 Material of the electrode
• CPC Class Codes: A61N 1/044 Shape of the electrode
• CPC Class Codes: A61N 1/0444 Membrane
• CPC Class Codes: A61N 1/0448 Drug reservoir
• CPC Class Codes: A61N 1/30 Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
• CPC Class Codes: A61N 1/325 for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body electrodes for external use A61N1/0428
• CPC Class Codes: G16H 20/10 relating to drugs or medications, e.g. for ensuring correct administration to patients
• CPC Class Codes: G16H 40/67 for remote operation
• CPC Class Codes: H04L 2209/88 Medical equipments
• CPC Class Codes: H04L 63/0428 wherein the data content is protected, e.g. by encrypting or encapsulating the payload
• CPC Class Codes: H04L 63/10 for controlling access to devices or network resources
• CPC Class Codes: H04L 9/32 including means for verifying the identity or authority of a user of the system or for message authentication, e.g. authorization, entity authentication, data integrity or data verification, non-repudiation, key authentication or verification of credentials

Abstract

The present invention comprises an active agent reservoir that stores a quantity of an active agent, an active electrode element operable to apply an electrical potential of a first polarity to deliver at least a portion of the active agent to a biological interface from the iontophoresis device, and a communications port providing a communications path between the iontophoresis device and a remote device. A method of the invention comprises operating an interface system to remotely interact with iontophoresis devices useful in delivery of active agents to biological interfaces including providing a user interface at a location remote from at least some of the iontophoresis devices, communicating with at least two of the iontophoresis devices, and providing information about the iontophoresis devices via the user interface.

Claims

1. An iontophoresis device, comprising:

an active agent reservoir that stores a quantity of an active agent;

an active electrode element operable to apply an electrical potential of a first polarity to deliver at least a portion of the active agent to a biological interface from the iontophoresis device; and

a communications port providing a communications path between the iontophoresis device and a remote device wherein the remote device provides commands to the iontophoresis device that are encrypted.

2. The iontophoresis device of claim 1, further comprising:

a controller operable to decrypt the commands provided from the remote device via the communications port and to at least partially control the delivery of the active agent to the biological interface from the iontophoresis device based at least partially on the decrypted commands.

3. The iontophoresis device of claim 2 wherein the controller is configured to determine whether the commands provided from the remote device via the communications port are authorized, and to at least initially reject any commands that are determined not to be authorized.

4. The iontophoresis device of claim 2, further comprising:

at least one ion selective membrane position between the active agent reservoir and an exterior of the iontophoresis device to at least partially control the delivery of the active agent to the biological interface from the iontophoresis device.

5. The iontophoresis device of claim 2, further comprising:

at least one ion selective membrane position between the active electrode element and the active agent reservoir.

6. The iontophoresis device of claim 1, further comprising:

a user interface operable by a user to receive user generated operational requests; and

a controller operable to decrypt the commands provided from the remote device via the communications port in response to authorizing requests provided from the controller to the remote device based on the user generated operational requests and to at least partially control the delivery of the active agent to the biological interface from the iontophoresis device based at least partially on the decrypted commands.

7. The iontophoresis device of claim 6 wherein the controller is configured to encrypt authorizing requests to the remote device via the communications port.

8. The iontophoresis device of claim 6 wherein the controller is configured to determine whether the commands provided from the remote device via the communications port are authorized, and to at least initially reject any commands that are determined not to be authorized.

9. An iontophoresis interface system, comprising:

a user interface operable by a user to produce user generated requests and to provide information to the user;

a communications port providing a communications path between the iontophoresis interface system and at least one iontophoresis device remotely located with respect to the iontophoresis interface system; and

a processor coupled to control communications with the at least one iontophoresis device via the communications port based at least in part on the user generated requests.

10. The iontophoresis interface system of claim 9 wherein in user interface is operable to produce user generated requests for information indicative of an operational condition of the at least one iontophoresis device.

11. The iontophoresis interface system of claim 9 wherein in user interface is operable to produce user generated requests for information indicative of a rate of transfer of an active agent by the at least one iontophoresis device, and to provide information to the user indicative of the rate of transfer of an active agent by the at least one iontophoresis device.

12. The iontophoresis interface system of claim 9 wherein in user interface is operable to produce user generated requests for information indicative of an amount of an active agent transferred by the at least one iontophoresis device, and to provide information to the user indicative of the amount of an active agent transferred by the at least one iontophoresis device.

13. The iontophoresis interface system of claim 9 wherein in user interface is operable to produce user generated requests for information indicative of a current flow through at least a portion of the at least one iontophoresis device, and to provide information to the user indicative of the current flow through at least a portion of the at least one iontophoresis device.

14. The iontophoresis interface system of claim 9 wherein in user interface is operable to produce user generated requests for information indicative of a voltage across at least a portion of the at least one iontophoresis device, and to provide information to the user indicative of the voltage across at least a portion of the at least one iontophoresis device.

15. The iontophoresis interface system of claim 9 wherein in user interface is operable to produce user generated requests for information indicative of a time during which the iontophoresis device has been at least one of active or inactive, and to provide information to the user indicative of the time during which the iontophoresis device has been at least one of active or inactive.

16. The iontophoresis interface system of claim 9 wherein in user interface is operable to produce user generated requests for information indicative of a delivery profile of the active agent over a period of time, and to provide information to the user indicative of the delivery profile of the active agent over the period of time.

17. The iontophoresis interface system of claim 9 wherein the communications port comprises at least one antenna element.

18. The iontophoresis interface system of claim 9 wherein the communications port comprises at least one communications connector.

19. The iontophoresis interface system of claim 9 wherein the communications path is at least one of a wired network connection or wireless network connection.

20. The iontophoresis interface system of claim 9 wherein the processor is operable to provide commands to the at least one iontophoresis device from the iontophoresis interface system via the communications port based at least in part on the user generated requests.

21. The iontophoresis interface system of claim 20 wherein at least some of the commands provided by the iontophoresis interface system to the at least one iontophoresis device are indicative of a delivery rate for delivering active agent to a biological interface from the iontophoresis device.

22. The iontophoresis interface system of claim 20 wherein at least some of the commands provided by the iontophoresis interface system to the at least one iontophoresis device are indicative of an amount of an active agent to deliver to a biological interface from the iontophoresis device.

23. The iontophoresis interface system of claim 20 wherein at least some of the commands provided by the iontophoresis interface system to the at least one iontophoresis device are indicative of a current flow through at least a portion of the iontophoresis device.

24. The iontophoresis interface system of claim 20 wherein at least some of the commands provided by the iontophoresis interface system to the at least one iontophoresis device are indicative of a voltage across at least a portion of the iontophoresis device.

25. The iontophoresis interface system of claim 20 wherein at least some of the commands provided by the iontophoresis interface system to the at least one iontophoresis device are indicative of a time during which the iontophoresis device is to actively deliver an active agent to a biological interface.

26. The iontophoresis interface system of claim 20 wherein at least some of the commands provided by the iontophoresis interface system to the at least one iontophoresis device are indicative of a delivery profile for delivering an active agent from the iontophoresis device to a biological interface.

27. The iontophoresis interface system of claim 20 wherein the communications port comprises at least one antenna element.

28. The iontophoresis interface system of claim 20 wherein the communications port comprises at least one communications connector.

29. The iontophoresis interface system of claim 20 wherein the communications path is at least one of a wired network connection or wireless network connection.

30. An iontophoresis system, comprising:

at least a first iontophoresis device operable to deliver an active agent to a biological interface, the first iontophoresis device comprising an active agent reservoir that stores a quantity of the active agent and an active electrode element operable to apply an electrical potential of a first polarity to deliver at least a portion of the active agent to the biological interface from the iontophoresis device; and

an iontophoresis interface system remotely located with respect to the first iontophoresis device, the iontophoresis interface system comprising a user interface operable by a user to produce user generated requests and to provide information to the user, a communications port providing a communications path between the iontophoresis interface system and the at least one iontophoresis device, and a processor coupled to control communications with the at least one iontophoresis device via the communications port based at least in part on the user generated requests.

31. The iontophoresis system of claim 30 wherein the first iontophoresis device further comprises a controller operable to at least partially control the delivery of the active agent to the biological interface from the iontophoresis device, wherein the controller is responsive to commands provided from the iontophoresis interface system via the communications port.

32. The iontophoresis system of claim 31 wherein the controller decrypts the commands provided from the iontophoresis interface system via the communications port.

33. The iontophoresis system of claim 31 wherein the controller is operable to determine whether the commands provided from the iontophoresis interface system via the communications port are authorized, and to at least initially reject any commands that are determined not to be authorized.

34. The iontophoresis system of claim 30 wherein the iontophoresis device comprises a user interface operable by a user to receive user generated operational requests and a controller operable to at least partially control the delivery of the active agent to the biological interface from the iontophoresis device, and wherein the controller is operable to provide authorizing requests to the iontophoresis interface system based on the user generated operational requests, and is responsive to commands provided from the iontophoresis interface system via the communications port in response to the authorizing requests.

35. The iontophoresis system of claim 34 wherein the controller encrypts authorizing requests to the iontophoresis interface system and decrypts the commands provided from the iontophoresis interface system via the communications port.

36. The iontophoresis system of claim 34 wherein the controller is operable to determine whether the commands provided from the iontophoresis interface system via the communications port are authorized, and to at least initially reject any commands that are determined not to be authorized.

37. The iontophoresis system of claim 30 wherein the iontophoresis device further comprises a monitoring subsystem operable to monitor at least one operational aspect of the iontophoresis device and coupled to the communications port to provide signals indicative of the monitored operational aspect to the iontophoresis interface system via the communications path.

38. The iontophoresis system of claim 37 wherein the monitoring subsystem is implemented in a controller operable to at least partially control the delivery of the active agent to the biological interface from the iontophoresis device, wherein the controller is responsive to commands provided from the iontophoresis interface system via the communications port.

39. The iontophoresis system of claim 37 wherein the monitoring subsystem monitors a rate of delivery of the active agent.

40. The iontophoresis system of claim 37 wherein the monitoring subsystem monitors an amount of the active agent delivered by the iontophoresis device.

41. The iontophoresis system of claim 37 wherein the monitoring subsystem monitors a current flow through at least a portion of the iontophoresis device.

42. The iontophoresis system of claim 37 wherein the monitoring subsystem monitors voltage across at least a portion of the iontophoresis device.

43. The iontophoresis system of claim 37 wherein the monitoring subsystem monitors a time during which the iontophoresis device has been at least one of active or inactive.

44. The iontophoresis system of claim 37 wherein the monitoring subsystem monitors a delivery profile of the active agent over a period of time.

45. The iontophoresis system of claim 30 wherein the user interface is operable to produce user generated requests for information indicative of an operational condition of the iontophoresis device and to provide information to the user indicative of the operational condition.

46. The iontophoresis interface system of claim 30 wherein in the user interface is operable to produce user generated requests for information indicative of a rate of transfer of the active agent by the at least one iontophoresis device, and to provide information to the user indicative of the rate of transfer of the active agent by the at least one iontophoresis device.

47. The iontophoresis interface system of claim 30 wherein in the user interface is operable to produce user generated requests for information indicative of an amount of the active agent transferred by the at least one iontophoresis device, and to provide information to the user indicative of the amount of the active agent transferred by the at least one iontophoresis device.

48. The iontophoresis interface system of claim 30 wherein the user interface is operable to produce user generated requests for information indicative of a current flow through at least a portion of the at least one iontophoresis device, and to provide information to the user indicative of the current flow through at least a portion of the at least one iontophoresis device.

49. The iontophoresis interface system of claim 30 wherein the user interface is operable to produce user generated requests for information indicative of a voltage across at least a portion of the at least one iontophoresis device, and to provide information to the user indicative of the voltage across at least a portion of the at least one iontophoresis device.

50. The iontophoresis interface system of claim 30 wherein the user interface is operable to produce user generated requests for information indicative of a time during which the iontophoresis device has been at least one of active or inactive, and to provide information to the user indicative of the time during which the iontophoresis device has been at least one of active or inactive.

51. The iontophoresis interface system of claim 30 wherein in user interface is operable to produce user generated requests for information indicative of a delivery profile of the active agent over a period of time, and to provide information to the user indicative of the delivery profile of the active agent over the period of time.

52. The iontophoresis system of claim 30 wherein the processor is operable to provide commands to the first iontophoresis device from the iontophoresis interface system via the communications port based at least in part on the user generated requests.

53. The iontophoresis system of claim 52 wherein at least some of the commands provided by the iontophoresis interface system to the at least one iontophoresis device are indicative of a delivery rate for delivering active agent to a biological interface from the iontophoresis device.

54. The iontophoresis system of claim 52 wherein at least some of the commands provided by the iontophoresis interface system to the at least one iontophoresis device are indicative of an amount of an active agent to deliver to a biological interface from the iontophoresis device.

55. The iontophoresis system of claim 52 wherein at least some of the commands provided by the iontophoresis interface system to the at least one iontophoresis device are indicative of a current flow through at least a portion of the iontophoresis device.

56. The iontophoresis system of claim 52 wherein at least some of the commands provided by the iontophoresis interface system to the at least one iontophoresis device are indicative of a voltage across at least a portion of the iontophoresis device.

57. The iontophoresis system of claim 52 wherein at least some of the commands provided by the iontophoresis interface system to the at least one iontophoresis device are indicative of a time during which the iontophoresis device is to actively deliver an active agent to a biological interface.

58. The iontophoresis system of claim 52 wherein at least some of the commands provided by the iontophoresis interface system to the at least one iontophoresis device are indicative of a delivery profile for delivering the active agent from the iontophoresis device to the biological interface.

59. The iontophoresis system of claim 30 wherein the communications port comprises at least one antenna element.

60. The iontophoresis system of claim 30 wherein the communications port comprises at least one communications connector.

61. The iontophoresis system of claim 30 wherein the communications path is at least one of a wired network connection or wireless network connection.

62. A method for operating an iontophoresis device, the method comprising:

storing a quantity of an active agent in an active agent reservoir;

delivering at least a portion of the active agent to a biological interface from the iontophoresis device by applying an electrical potential of a first polarity to an active electrode element;

communicating between the iontophoresis device and a remote device via a communications port; and

decrypting commands provided from the remote device via the communications port.

63. The method of claim 62, further comprising:

at least partially controlling the delivery of the active agent to the biological interface from the iontophoresis device upon decrypting the commands provided from the remote device via the communications port.

64. The method of claim 63 wherein communicating between the iontophoresis device and the remote device includes determining whether the commands provided from the remote device via the communications port are authorized, and to at least initially reject any commands that are determined not to be authorized.

65. The method of claim 62 wherein communicating between the iontophoresis device and the remote device comprises receiving user generated operational requests via a user interface operable by a user and providing authorizing requests to the remote device via the communications port based on the user generated operational requests, and upon decrypting the commands provided from the remote device via the communications port in response to the authorizing requests, responding to the commands.

66. The method of claim 65 wherein providing authorizing requests and responding to the commands include at least one of providing wired or wireless authorizing requests.

67. The method of claim 65 wherein providing authorizing requests to the remote device via the communications port includes encrypting the authorizing requests.

68. The method of claim 65 wherein responding to the commands provided from the remote device via the communications port includes determining whether the commands are authorized, and to at least initially reject any commands that are determined not to be authorized.

69. A method operating an interface system to remotely interact with iontophoresis devices useful in delivery of active agents to biological interfaces, the method comprising:

providing a user interface at a location remote from at least some of the iontophoresis devices;

communicating with at least two of the iontophoresis devices; and

providing information about the iontophoresis devices via the user interface.

70. The method of claim 69, further comprising:

producing a number of requests for operational parameter information, wherein communicating with at least two of the iontophoresis devices includes communicating the requests for operational parameter information to the respective iontophoresis device and receiving a response to the request.

71. The method of claim 70 wherein providing information about the iontophoresis devices via the user interface includes providing information based at least in part on the received response to the request.

72. The method of claim 70 wherein producing a number of requests for operational parameter information comprises producing requests for information indicative of a rate of transfer of an active agent by the at least one iontophoresis device and providing information to the user indicative of the rate of transfer of the active agent by the at least one iontophoresis device.

73. The method of claim 70 wherein producing a number of requests for operational parameter information comprises producing requests for information indicative of an amount of an active agent transferred by the at least one iontophoresis device and providing information to the user indicative of the amount of the active agent transferred by the at least one iontophoresis device.

74. The method of claim 70 wherein producing a number of requests for operational parameter information comprises producing requests for information indicative of a current flow through at least a portion of the at least one iontophoresis device and providing information to the user indicative of the current flow through the at least one iontophoresis device.

75. The method of claim 70 wherein producing a number of requests for operational parameter information comprises producing requests for information indicative of a voltage across at least a portion of the at least one iontophoresis device and providing information to the user indicative of the voltage across at least a portion of the at least one iontophoresis device.

76. The method of claim 70 wherein producing a number of requests for operational parameter information comprises producing requests for information indicative of a time during which the iontophoresis device has been at least one of active or inactive and providing information to the user indicative of the time during which the iontophoresis device has been at least one of active or inactive.

77. The method of claim 70 wherein producing a number of requests for operational parameter information comprises producing requests for information indicative of a delivery profile of the active agent over a period of time and providing information to the user indicative of the delivery profile of the active agent over the period of time.

78. The method of claim 69 wherein communicating with at least two of the iontophoresis devices comprises providing at least one of wired or wireless communications.

79. The method of claim 69 wherein communicating with at least two of the iontophoresis devices comprises providing commands to the iontophoresis devices.

80. The method of claim 79 wherein providing commands to the iontophoresis devices comprises providing commands indicative of a delivery rate for delivering an active agent to a biological interface from the iontophoresis device.

81. The method of claim 79 wherein providing commands to the iontophoresis devices comprises providing commands indicative of an amount of an active agent to deliver to a biological interface from the iontophoresis device.

82. The method of claim 79 wherein providing commands to the iontophoresis devices comprises providing commands indicative of a current flow through at least a portion of the iontophoresis device.

83. The method of claim 79 wherein providing commands to the iontophoresis devices comprises providing commands indicative of a voltage across at least a portion of the iontophoresis device.

84. The method of claim 79 wherein providing commands to the iontophoresis devices comprises providing commands indicative of a time during which the iontophoresis device is to actively deliver an active agent to a biological interface.

85. The method of claim 79 wherein providing commands to the iontophoresis devices comprises providing commands indicative of a delivery profile for delivering an active agent from the iontophoresis device to a biological interface.

86. A method for operating an iontophoresis system, the method comprising:

providing communications between a plurality of iontophoresis devices and at least one iontophoresis interface system remotely located from the iontophoresis devices;

operating the iontophoresis devices at least in part on commands received from the iontophoresis interface system; and

at least temporarily storing operational condition information at the iontophoresis interface system, the operational condition information indicative of at least one operating parameter for a number of the iontophoresis devices.

87. The method of claim 86 wherein operating the iontophoresis devices at least in part on commands received from the control system comprises at least partially controlling the delivery of an active agent to a biological interface from the iontophoresis device in response to the commands provided from the iontophoresis interface system via the communications port.

88. The method of claim 87 wherein providing communications between a plurality of iontophoresis devices and at least one iontophoresis interface system remotely located from the iontophoresis devices comprises decrypting the commands provided from the iontophoresis interface system.

89. The method of claim 87 wherein providing communications between a plurality of iontophoresis devices and at least one iontophoresis interface system remotely located from the iontophoresis devices comprises determining whether the commands provided from the iontophoresis interface system are authorized, and to at least initially reject any commands that are determined not to be authorized.

90. The method of claim 87 wherein providing communications between a plurality of iontophoresis devices and at least one iontophoresis interface system remotely located from the iontophoresis devices comprises providing to the iontophoresis interface system requests for authorization to adjust an operational condition of the iontophoresis device.

91. The method of claim 90 wherein requests for authorization to adjust an operational condition of the iontophoresis device are produced in response to user generated operational requests.

92. The method of claim 86, further comprising:

monitoring at least one operational aspect of the iontophoresis device and providing signals indicative of the monitored operational aspect to the iontophoresis interface system.

93. The method of claim 92 wherein monitoring at least one operational aspect of the iontophoresis device includes monitoring a rate of delivery of an active agent from the iontophoresis device.

94. The method of claim 92 wherein monitoring at least one operational aspect of the iontophoresis device includes monitoring an amount of an active agent delivered by the iontophoresis device.

95. The method of claim 92 wherein monitoring at least one operational aspect of the iontophoresis device includes monitoring a current flow through at least a portion of the iontophoresis device.

96. The method of claim 92 wherein monitoring at least one operational aspect of the iontophoresis device includes monitoring voltage across at least a portion of the iontophoresis device.

97. The method of claim 92 wherein monitoring at least one operational aspect of the iontophoresis device includes monitoring a time during which the iontophoresis device has been at least one of active or inactive.

98. The method of claim 92 wherein monitoring at least one operational aspect of the iontophoresis device includes monitoring a delivery profile indicative of a delivery of an active agent by the iontophoresis device over a period of time.

99. The method of claim 86, further comprising:

presenting the operational condition information via a user interface remotely from the iontophoresis devices.

100. The method of claim 86 wherein providing communications between a plurality of iontophoresis devices and at least one iontophoresis interface system remotely located from the iontophoresis devices comprises providing at least one of wired or wireless communications between the iontophoresis devices and the at least one iontophoresis interface system.