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Closed-loop state-dependent seizure prevention systems

  • US 20070213786A1
  • Filed: 12/19/2006
  • Published: 09/13/2007
  • Est. Priority Date: 12/19/2005
  • Status: Abandoned Application
First Claim
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1. A closed-loop state-dependent neuroprosthetic device for seizure prevention wherein control of electrical stimulation intervention is determined by the dynamical electrophysiological state of a neural structure being monitored, comprising:

  • a detection system that detects and collects electrophysiological information detectable by electroencephalography (EEG) from a neural structure in a subject;

    an analysis system that evaluates the detected and collected electrophysiological information and performs a real-time extraction of said information to obtain electrophysiological features associated with a pre-seizure state in the neural structure, and from the extracted features determines when electrical stimulus intervention is required; and

    an electrical stimulation intervention system that provides electrical stimulation output signals having desired stimulation parameters to a neural structure being monitored and in which abnormal neuronal activity is detected;

    wherein the analysis system further analyzes collected electrophysiological information following electrical stimulation intervention to assess the short-term effects of the stimulation intervention and to provide feedback to maintain or modify such stimulation intervention.

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