Method and apparatus for stenting comprising enhanced embolic protection coupled with improved protections against restenosis and thrombus formation

• US 20070213800A1
• Filed: 03/30/2007
• Published: 09/13/2007
• Est. Priority Date: 09/05/1998
• Status: Active Grant

• Current Assignee: Abbott Laboratories Limited (Abbott Laboratories Incorporated)
• Original Assignee: Abbott Laboratories Limited (Abbott Laboratories Incorporated)
• Inventors: Seibold, Gerd, von Oepen, Randolf, Gianotti, Marc, Schaffner, Silvio, Fierens, Joost
• Granted Patent: US 8,088,157 B2
• Time in Patent Office: Days
• US Class Current: 623/1.200
• CPC Class Codes: A61F 2/07 Stent-grafts
• CPC Class Codes: A61F 2/82 Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95; for closing wounds, or holding wounds closed A61B17/04 - A61B17/115; dilators A61M29/00
• CPC Class Codes: A61F 2/856 Single tubular stent with a side portal passage
• CPC Class Codes: A61F 2/90 characterised by a net-like or mesh-like structure
• CPC Class Codes: A61F 2/91 made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
• CPC Class Codes: A61F 2/915 with bands having a meander structure, adjacent bands being connected to each other
• CPC Class Codes: A61F 2/958 Inflatable balloons for placing stents or stent-grafts
• CPC Class Codes: A61F 2002/0086 for preferentially controlling or promoting the growth of specific types of cells or tissues of bone tissue onto implantable joints A61F2002/3093
• CPC Class Codes: A61F 2002/91508 the meander having a difference in amplitude along the band
• CPC Class Codes: A61F 2002/91533 characterised by the phase between adjacent bands
• CPC Class Codes: A61F 2002/91558 connected peak to peak
• CPC Class Codes: A61F 2220/0008 Fixation appliances for connecting prostheses to the body
• CPC Class Codes: A61F 2220/0016 with sharp anchoring protrusions, e.g. barbs, pins, spikes
• CPC Class Codes: A61F 2220/005 using adhesives
• CPC Class Codes: A61P 7/02 Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
• CPC Class Codes: A61P 9/10 for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

Apparatus and methods for stenting are provided comprising a stent attached to a porous biocompatible material that is permeable to endothelial cell ingrowth, but impermeable to release of emboli of predetermined size. Preferred stent designs are provided, as well as preferred manufacturing techniques. Apparatus and methods are also provided for use at a vessel branching. Moreover, embodiments of the present invention may comprise a coating configured for localized delivery of therapeutic agents. Embodiments of the present invention are expected to provide enhanced embolic protection, improved force distribution, and improved recrossability, while reducing a risk of restenosis and thrombus formation.

Claims

1. A covered endoprosthesis comprising:

a generally tubular member having inner and outer surfaces defining a wall, a pattern within the wall defining a web structure configured for expansion from a collapsed position to an expanded position; and

a membrane disposed about at least a portion of the tubular member, a plurality of pores being formed in the membrane, the membrane being configured to reduce emboli release from the wall into a lumen upon expansion of the tubular member into the lumen from the collapsed position to the expanded position.

2. The covered endoprosthesis according to claim 1, wherein the membrane is formed by a weaving, knitting or braiding process.

3. The covered endoprosthesis according to claim 1, wherein the pores have a minimum width of approximately 30 μ

m or more.

4. The covered endoprosthesis of claim 3, wherein the pores comprise a maximum width of about 100 μ

m or less.

5. The covered endoprosthesis of claim 1, wherein the membrane further includes a coating.

6. The covered endoprosthesis of claim 5, wherein the coating comprises a therapeutic agent.

7. The covered endoprosthesis according to claim 1, wherein the membrane is disposed about at least a portion of the outer surface of the tubular member.

8. The covered endoprosthesis according to claim 7, wherein the membrane is further disposed about at least a portion of the inner surface of the tubular member.

9. The covered endoprosthesis according to claim 1, wherein one or more of the plurality of pores is sized to allow blood flow therethrough.

10. The covered endoprosthesis according to claim 9, further including a radial opening formed in the web pattern, wherein at least one of the one or more pores sized to allow blood flow therethrough are positioned within the radial opening.

11. The covered endoprosthesis according to claim 1, wherein the tubular member is self-expanding.

12. The covered endoprosthesis according to claim 1, wherein the tubular member is balloon expandable.

13. The covered endoprosthesis according to claim 1, wherein the pores formed in the membrane are uneven in size and placement.

14. A covered endoprosthesis comprising:

a generally tubular member having inner and outer surfaces defining a wall and first end and second ends, a pattern within the wall defining a web structure configured for expansion from a collapsed position to an expanded position; and

a membrane disposed about at least a portion of the tubular member, a plurality of pores being formed in the membrane, the membrane being configured to reduce emboli release from the wall into a lumen upon expansion into the lumen of the tubular member from the collapsed position to the expanded position, the pores having different sizes in different positions between the first and the second ends of the tubular member.

15. The covered endoprosthesis according to claim 16, wherein the membrane is formed by a weaving, knitting or braiding process.

16. The covered endoprosthesis according to claim 14, wherein the membrane includes a coating comprising a therapeutically beneficial agent.

17. An apparatus for stenting comprising:

a stent having first and second ends and a lumen extending therebetween, the stent configured for expansion from a collapsed position to an expanded position; and

a material disposed about a surface of the stent, the material having a plurality of pores formed along its length.

18. The apparatus for stenting according to claim 17, wherein the plurality of pores are formed along the entire length of the stent.

19. The apparatus for stenting according to claim 17, wherein the material is disposed about an exterior surface of the stent.

20. The apparatus according to claim 17, further comprising a therapeutic coating disposed on the material.