Microfluidic chip capable of synthesizing radioactively labeled molecules on a scale suitable for human imaging with positron emission tomography
2 Assignments
0 Petitions
Accused Products
Abstract
Described herein are automated, integrated microfluidic device comprising a chemical reaction chip comprising for performing chemical reaction, a microscale column integrated with the chip and configured for liquid flow from the column to at least one flow channel, and wherein the fluid flow into the column is controlled by on-chip valves; and comprising at least two on-chip valves for controlling fluid flow in the microfluidic device.
197 Citations
39 Claims
-
1-24. -24. (canceled)
-
25. An automated, integrated microfluidic device for performing chemical reactions and for processing of reaction products, the device comprising:
-
a chemical reaction chip comprising;
a substrate comprising a microfluidic a network of flow channels for moving reagents, solvents and products through the chip;
a substantially coin-shaped reaction chamber for introducing reagents and solvents for performing the chemical reaction, the chamber comprising at least one inlet channel configured to be in fluid communication with at least one flow channel for introducing reagents and solvents into the chamber, and at least one outlet channel for transferring a solution comprising reagent and product from the chamber;
a manifold comprising multiport inlet channels and valves, configured for controlling reagent and/or a solvent flow, in fluid communication with the reaction chamber;
a pump operatively interconnected and in fluid communication with the flow channel for pumping reagents, solvents and products through the flow channel and chip;
a casing, which is impermeable to radioactivity emanating from the positron and gamma-emitters employed;
a microscale chromatography column for isolating or purifying reagents used for performing the chemical reaction, wherein the column is integrated with the chip and configured with column inlet channels and outlet channels for fluid flow to introduce reagents and/or solvents into the column and from the column to at least one flow channel to the reaction chamber, and wherein the liquid flow into the column is controlled by on-chip valves; and
at least two on-chip valves for controlling reagents, solvents and products flow among the column, the flow channels, the manifold, and the reaction chamber in the microfluidic device. - View Dependent Claims (26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39)
-
Specification