Surface-Modified Metal Oxides Methods for Production and Use Thereof in Cosmetic Preparations

• US 20070218019A1
• Filed: 03/26/2005
• Published: 09/20/2007
• Est. Priority Date: 03/31/2004
• Status: Abandoned Application

• Current Assignee: BASF AG (BASF SE)
• Original Assignee: BASF AG (BASF SE)
• Inventors: Andre, Valerie, Debus, Heidrun, Rieger, Jens
• Application Number:
  US10/594,735
• Publication Number:
  US 20070218019A1
• Time in Patent Office: Days
• US Class Current: 424/59
• CPC Class Codes: A61K 2800/413 Nanosized, i.e. having sizes below 100 nm
• CPC Class Codes: A61K 8/19 containing inorganic ingredients
• CPC Class Codes: A61K 8/27 Zinc; Compounds thereof
• CPC Class Codes: A61K 8/64 Proteins; Peptides; Derivatives or degradation products thereof
• CPC Class Codes: A61Q 17/04 Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
• CPC Class Codes: B82Y 30/00 Nanotechnology for materials or surface science, e.g. nanocomposites
• CPC Class Codes: B82Y 5/00 Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
• CPC Class Codes: C01P 2004/62 Submicrometer sized, i.e. from 0.1-1 micrometer
• CPC Class Codes: C01P 2004/64 Nanometer sized, i.e. from 1-100 nanometer
• CPC Class Codes: C09C 1/043 Zinc oxide
• CPC Class Codes: C09C 1/24 Oxides of iron
• CPC Class Codes: C09C 1/3676 Treatment with macro-molecular organic compounds
• CPC Class Codes: C09C 1/40 Compounds of aluminium C09C1/0009, C09C1/0015, C09C1/0078, C09C1/32 take precedence
• CPC Class Codes: C09C 3/10 Treatment with macromolecular organic compounds C09C3/006 takes precedence
• CPC Class Codes: Y10T 428/12993 Surface feature [e.g., rough, mirror]

Abstract

The present invention relates to surface-modified nanoparticulate metal oxides, methods for their production and use thereof as UV filters in cosmetic preparations.

Claims

1. A surface-modified nanoparticulate metal oxide, where the metal is chosen from the group consisting of aluminum, cerium, iron, titanium, zinc and zirconium, wherein

a) the surface modification comprises a coating with polyasparaginic acid with a molecular weight M_w of from 1000 to 100 000, and

b) the metal oxide particles have an average primary particle diameter of from 5 to 10 000 nm.

2. The metal oxide according to claim 1, wherein it is surface-modified zinc oxide.

10. The use of surface-modified nanoparticulate metal oxides defined according to claim 1 for producing cosmetic preparations.

11. The use according to claim 10 for producing cosmetic sunscreen preparations.

12. A cosmetic preparation comprising surface-modified nanoparticulate metal oxides defined according to claim 1.

3. A method of producing a surface-modified nanoparticulate metal oxide, where the metal is chosen from the group consisting of aluminum, cerium, iron, titanium, zinc and zirconium, by

a. precipitation of the metal oxide from an aqueous solution of one of its metal salts,

b. separating off the precipitated metal oxide from the aqueous reaction mixture and

c. subsequent drying of the metal oxide,

wherein the precipitation of the metal oxide in process step a. takes place in the presence of polyasparaginic acid.

4. The method according to claim 3, wherein the metal salts are metal halides, acetates, sulfates or nitrates.

5. The method according to claim 3, wherein the precipitation takes place in the presence of polyasparaginic acid with a molecular weight M_w of from 1000 to 100 000.

6. The method according to claim 3, wherein the precipitation takes place at a temperature in the range from 20°

C. to 100°

C.

7. The method according to claim 3, wherein the precipitation takes place at a pH in the range from 3 to 12.

8. The method according to claim 3 for producing surface-modified nanoparticulate zinc oxide.

9. The method according to claim 8, wherein the precipitation of the zinc oxide in process step a. takes place from an aqueous solution of zinc(II) chloride or zinc(II) nitrate at a temperature in the range from 25 to 40°

C. and a pH in the range from 7 to 11 in the presence of polyasparaginic acid with a molecular weight M_w of from 1000 to 7000.

13. The method according to claim 4, wherein the precipitation takes place in the presence of polyasparaginic acid with a molecular weight M_w of from 1000 to 100 000.

14. The method according to claim 4, wherein the precipitation takes place at a temperature in the range from 20°

C. to 100°

C.

15. The method according to claim 5, wherein the precipitation takes place at a temperature in the range from 20°

C. to 100°

C.

16. The method according to claim 4, wherein the precipitation takes place at a pH in the range from 3 to 12.

17. The method according to claim 5, wherein the precipitation takes place at a pH in the range from 3 to 12.

18. The method according to claim 6, wherein the precipitation takes place at a pH in the range from 3 to 12.

19. The method according to claim 4 for producing surface-modified nanoparticulate zinc oxide.

20. The method according to claim 5 for producing surface-modified nanoparticulate zinc oxide.