Method of controlled release of vanillin for nasal and/or pulmonary uptake

• US 20070218087A1
• Filed: 05/21/2007
• Published: 09/20/2007
• Est. Priority Date: 12/07/2001
• Status: Abandoned Application

• Current Assignee: Pa Dr. Ernst-Peter Heilein
• Original Assignee: Pa Dr. Ernst-Peter Heilein
• Inventors: Hoenzelaer, Norbert
• Application Number:
  US11/804,842
• Publication Number:
  US 20070218087A1
• Time in Patent Office: Days
• US Class Current: 424/400
• CPC Class Codes: A61K 31/11 Aldehydes
• CPC Class Codes: A61K 9/007 Pulmonary tract; Aromatherapy
• CPC Class Codes: A61K 9/7084 Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches

Abstract

A gaseous vanillin compound is continuously released for nasal and/or pulmonary uptake. The gaseous vanillin compound is provided in a patch having a layer that is impermeable to the gaseous vanillin compound, a layer permeable to the gaseous vanillin compound, and the vanillin localized between the two layers. The patch is placed on the person so as to stimulate the release of serotonin in the central nervous system and for utilizing the patch to reduce food cravings of the person in need thereof.

Claims

1. A method of assisting a person in need thereof to regulate the craving to consume food, which comprises:

providing a patch formed with a first layer substantially impermeable to a gaseous vanillin compound, a second layer permeable to the gaseous vanillin compound, and a composition comprising at least one vanillin compound disposed between the first and second layers;

the patch not comprising lint impregnated with the composition;

placing the patch on the person substantially below a head region with the first layer facing towards the person'"'"'s body, and continuously releasing the gaseous vanillin compound through the second layer for nasal or pulmonary uptake by the person wearing the patch to reduce a craving to consume food.

2. The method according to claim 1, which comprises adhering the patch to the person'"'"'s skin in a chest area.

3. The method according to claim 1, which comprises providing the patch with fully compliant first and second layers not including a resilient portion.

4. The method according to claim 1, wherein said at least one vanillin compound is selected from the group consisting of vanillin and ethylvanillin.

5. The method according to claim 1, further comprising a first, protective liner layer attached adhesively to the side of said impermeable layer, and a second protective liner layer, which is impermeable to the at least one gaseous vanillin compound, attached adhesively to the permeable layer on its side that is facing away from the impermeable layer.

6. The method according to claim 1, wherein the composition has a dynamic viscosity in a range from 10² to 10⁶ mPa·

s at 20°

C. in accordance with DIN 53211.

7. The method according to claim 6, wherein the composition has a dynamic viscosity in a range from 10³ to 10⁵ mPa·

s at 20°

C. in accordance with DIN 53211.

8. The method according to claim 1, wherein the composition is based on:

(α

1) vanillin and/or ethyl vanillin in an amount in a range from 0.1% to 100% by weight;

(α

2) a vehicle in an amount in a range from 0% to 99% by weight; and

(α

3) excipients in an amount in a range from 0% to 50% by weight;

a sum of components (α

1) to (α

3) being 100% by weight.

9. The method according to claim 8, wherein said vehicle comprises synthetic rubber.

10. The method according to claim 1, which comprises adjusting a thickness of the first layer impermeable to the at least one gaseous vanillin compound such that within a time interval of 24 hours not more than 1% by weight of the composition can evaporate via this film at room temperature under a pressure of 1 bar.

11. The method according to claim 10, wherein said layer has a thickness in a range from 0.001 to 1 mm.

12. The method according to claim 1, which comprises adjusting the second layer permeable to the gaseous vanillin compound with a permeability to allow, within a time interval of 18 to 24 hours, at least 10% by weight of the at least one vanillin compound present in the composition to evaporate at room temperature under a pressure of 1 bar.

13. The method according to claim 12, wherein the permeable layer comprises a film comprising polyethylene, polyamide, ethylene-vinyl acetate copolymer or mixtures thereof.

14. The method according to claim 12, wherein said permeable layer has a thickness in a range from 0.001 to 1 mm.

15. The method according to claim 1, wherein the permeable layer is a film formed with holes having a diameter in a range between 1 and 100 Å

.

16. The method according to claim 1, which comprises forming the second layer as a film with holes and a given density, such that within a time interval of 24 hours at room temperature under a pressure of 1 bar at least 10% by weight of the vanillin and/or ethyl vanillin present in the composition is able to evaporate.

17. The method according to claim 16, wherein the film is adjusted such that within a time interval of 24 hours at room temperature under a pressure of 1 bar at least 25% by weight of the vanillin and/or ethyl vanillin present in the composition is able to evaporate.

18. The method according to claim 16, wherein the film is adjusted such that within a time interval of 24 hours at room temperature under a pressure of 1 bar at least 50% by weight of the vanillin and/or ethyl vanillin present in the composition is able to evaporate.

19. The method according to claim 1, wherein said impermeable layer comprises aluminum foil.

20. A method of stimulating a release of serotonin in the central nervous system of a person, the method which comprises:

providing a patch formed with a first layer substantially impermeable to a gaseous vanillin compound, a second layer permeable to the gaseous vanillin compound, and a composition comprising at least one vanillin compound disposed between the first and second layers, the patch not comprising lint impregnated with the composition;

placing the patch on the person substantially below a head region with the first layer facing towards the person'"'"'s body, and continuously releasing the gaseous vanillin compound through the second layer for nasal or pulmonary uptake by the person wearing the patch to influence a serotonin exchange in the central nervous system of the person.