Polymerizable emulsions for tissue engineering
First Claim
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1. A method of preparing a strong, nontoxic, viscoelastic material for tissue engineering, wherein the viscoelastic material comprises two discrete phases, an organic phase and an aqueous phase, the method comprising:
- preparing a nontoxic, inverse (water-in-oil) fluid emulsion comprising two discrete phases;
a continuous hydrophobic organic (oil) phase, comprising one or more reactive, ethylenically unsaturated, polymerizable monomers, at least one polymerization initiator; and
a discontinuous aqueous (water) phase, wherein the aqueous phase concentration ranges from about 0.5% to about 90% weight/weight of the oil phase; and
polymerizing the emulsion in situ to form the viscoelastic material.
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Abstract
Provided are biocompatible viscoelastic solid materials derived from polymerization of fluid water-in-oil emulsions, along with methods of their preparation and methods for their use for tissue engineering applications, including for reforming diseased, damaged or degenerated intervertebral discs by acceptably non-invasive means.
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16 Claims
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1. A method of preparing a strong, nontoxic, viscoelastic material for tissue engineering, wherein the viscoelastic material comprises two discrete phases, an organic phase and an aqueous phase, the method comprising:
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preparing a nontoxic, inverse (water-in-oil) fluid emulsion comprising two discrete phases;
a continuous hydrophobic organic (oil) phase, comprising one or more reactive, ethylenically unsaturated, polymerizable monomers, at least one polymerization initiator; and
a discontinuous aqueous (water) phase, wherein the aqueous phase concentration ranges from about 0.5% to about 90% weight/weight of the oil phase; and
polymerizing the emulsion in situ to form the viscoelastic material. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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Specification