METHOD FOR REMOVAL OF VIRUSES FROM BLOOD BY LECTIN AFFINITY HEMODIALYSIS
First Claim
1. A method of using lectin to reduce the amount of viral particles or fragments thereof in blood or plasma contaminated with a viral particles or fragments thereof, comprising:
- providing a lectin affinity device comprising a processing chamber having lectin disposed within said processing chamber, wherein said lectin binds viral particles or fragments thereof and traps them in said processing chamber;
transferring blood or plasma contaminated with viral particles or fragments thereof into said chamber such that said viral particles or fragments thereof contact said lectin and are bound thereto; and
removing said blood or plasma from said chamber, wherein said removed blood or plasma has a reduced amount of viral particles or fragments thereof.
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Abstract
The present invention relates to a method for using lectins that bind to pathogens having high mannose surface glycoproteins or fragments thereof which contain high mannose glycoproteins, to remove them from infected blood or plasma in an extracorporeal setting. Accordingly, the present invention provides a method for reducing viral load in an individual comprising the steps of obtaining blood or plasma from the individual, passing the blood or plasma through a porous hollow fiber membrane wherein lectin molecules are immobilized within the porous exterior portion of the membrane, collecting pass-through blood or plasma and reinfusing the pass-through blood or plasma into the individual.
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Citations
68 Claims
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1. A method of using lectin to reduce the amount of viral particles or fragments thereof in blood or plasma contaminated with a viral particles or fragments thereof, comprising:
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providing a lectin affinity device comprising a processing chamber having lectin disposed within said processing chamber, wherein said lectin binds viral particles or fragments thereof and traps them in said processing chamber;
transferring blood or plasma contaminated with viral particles or fragments thereof into said chamber such that said viral particles or fragments thereof contact said lectin and are bound thereto; and
removing said blood or plasma from said chamber, wherein said removed blood or plasma has a reduced amount of viral particles or fragments thereof. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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27. A method of using lectin to reduce the amount of viral particles or fragments thereof in blood or plasma contaminated with viral particles or fragments thereof, comprising:
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passing blood or plasma contaminated with viral particles or fragments thereof through at least one porous hollow fiber membrane contained in a cartridges wherein lectin is disposed within an extrachannel space of said cartridge proximate to an exterior surface of said at least one membrane, and wherein the lectin binds viral particles or fragments thereof and traps them in said extrachannel space; and
collecting pass-through blood or plasma, wherein said pass-through blood or plasma has a reduced amount of viral particles or fragments thereof. - View Dependent Claims (28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41)
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42. A lectin affinity device for removing viral particles or fragments thereof from contaminated blood or plasma comprising:
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a processing chamber configured to receive blood or plasma contaminated with viral particles or fragments thereof;
lectin disposed within said processing chamber; and
a porous membrane, said membrane configured such that when blood or plasma contaminated with viral particles or fragments thereof is disposed in said processing chamber, viral particles or fragments thereof pass through said membrane and contact said lectin and are bound thereto, and wherein blood cells are prevented from passing through said membrane and contacting said lectin. - View Dependent Claims (43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68)
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Specification