Enhanced activity alcohol-based antimicrobial compositions

• US 20070219273A1
• Filed: 05/17/2007
• Published: 09/20/2007
• Est. Priority Date: 08/20/2004
• Status: Active Grant

• Current Assignee: SC Johnson & Son Incorporated
• Original Assignee: Steris Inc (Steris Corporation)
• Inventors: Klein, Daniel, Greten, Zachariah, Kaiser, Nancy-Hope
• Granted Patent: US 7,985,773 B2
• Time in Patent Office: Days
• US Class Current: 514/643
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 31/02 Acyclic compounds
• CPC Class Codes: A01N 31/04 Oxygen or sulfur attached to an aliphatic side-chain of a carbocyclic ring system
• CPC Class Codes: A01N 33/12 Quaternary ammonium compounds
• CPC Class Codes: A01N 37/12 containing the group , wherein Cn means a carbon skeleton not containing a ring; Thio analogues thereof
• CPC Class Codes: A01N 37/20 containing the group , wherein Cn means a carbon skeleton not containing a ring; Thio analogues thereof
• CPC Class Codes: A01N 39/00 Biocides, pest repellants or attractants, or plant growth regulators containing aryloxy- or arylthio-aliphatic or cycloaliphatic compounds, containing the group or , e.g. phenoxyethylamine, phenylthio-acetonitrile, phenoxyacetone
• CPC Class Codes: A61P 31/04 Antibacterial agents

Abstract

Antimicrobial compositions which can be used wherever disinfecting compositions are needed, such as in a hospital, healthcare industry, workplace, recreational facility, home or similar environment. The antimicrobial compositions are particularly useful as a topical application for a substrate, such as skin and can be used as a hand sanitizer or pre-surgical scrub. The compositions comprise a synergistic combination of a simple aliphatic alcohol and an activity enhancing substance, wherein the composition provides, heretofore unexpected, persistent activity against a broad range of microorganisms, including gram-negative organisms, while moisturizing the skin.

Claims

1. A composition having antimicrobial properties, comprising:

an aliphatic alcohol having from 1 to about 8 carbon atoms in an amount from about 30 to about 90 parts;

an aromatic alcohol in an amount from about 0.5 to about 5.0 parts, wherein the hydroxyl group of the aromatic alcohol is connected to a non-aromatic ring carbon atom;

a cationic substrate binding activity enhancing substance in an amount from about 0.0125 to about 0.5 part; and

water in an amount from about 5 to about 65 parts, all said parts based on 100 parts by weight of the composition, said composition free of a cationic cellulose polymer.

2-35. -35. (canceled)

36. A composition having antimicrobial properties, comprising:

an aliphatic alcohol having from 1 to about 8 carbon atoms in an amount from about 30 to less than 60 parts;

an aromatic alcohol in an amount from about 0.5 to about 5.0 parts, wherein the hydroxyl group of the aromatic alcohol is connected to a non-aromatic ring carbon atom;

a cationic substrate binding activity enhancing substance in an amount from about 0.0125 to about 0.5 part, wherein the cationic substrate binding activity enhancing substance is behenoyl PG-trimonium chloride, behenoyl PG-dimonium chloride, behenamidopropyl PG-dimonium chloride, or a combination thereof; and

water in an amount from about 33 to about 65 parts, all said parts based on 100 parts by weight of the composition, said composition free of a cationic cellulose polymer.

37. The composition according to claim 36, wherein the aliphatic alcohol is present in an amount from about 45 to less than 60 parts, and wherein the aromatic alcohol is present in an amount from 0.75 to about 3.5 parts.

38. The composition according to claim 37, wherein the water is present in an amount from about 33 to about 50 parts, and wherein the cationic substrate binding activity enhancing substance is present in an amount from 0.03 to about 0.1 part.

39. The composition according to claim 38, wherein the composition further includes a non-ionic thickener.

40. The composition according to claim 37, wherein the composition has a viscosity of from about 10 to about 100,000 centipoise, and wherein said aliphatic alcohol is methanol, ethanol, n-propanol, isopropyl alcohol, 2-methyl-2 propanol, hexanol, or combinations thereof.

41. The composition according to claim 40, wherein said aliphatic alcohol is present in an amount from about 50 to about 55 parts, and wherein said aromatic alcohol is present in an amount from about 1.0 to about 2.5 parts, and wherein said cationic substrate binding activity enhancing substance is present in an amount from about 0.04 to about 0.075 part.

42. The composition according to claim 41, wherein the aliphatic alcohol is propanol, isopropyl alcohol, or ethanol, or combinations thereof, and wherein said aromatic alcohol is phenoxyethanol, benzyl alcohol, 1-phenoxy-2-propanol, or combinations thereof.

43. The composition according to claim 39, wherein the non-ionic thickener is a cellulose-based thickener in an amount from about 0.1 to about 3.0 parts.

44. The composition according to claim 43, wherein the composition further includes a polyol, a skin conditioner, or pH adjusters or combinations thereof.

45. The composition according to claim 44, wherein the viscosity of the composition is 30 to about 120 centipoise, wherein the thickener comprises 2-hydroxypropyl cellulose, and wherein water is present in an amount from about 35 to about 45 parts.

46. A method for forming an antimicrobial composition, comprising the steps of:

providing from 33 to about 65 parts of water to a vessel;

adding a cationic substrate binding activity enhancing substance to the vessel in an amount from about 0.0125 to about 0.5 part, wherein the cationic substrate binding activity enhancing substance is behenoyl PG-trimonium chloride, behenoyl PG-dimonium chloride, behenamidopropyl PG-dimonium chloride, or a combination thereof;

adding an aromatic alcohol to the vessel in an amount from about 0.5 to about 5.0 parts, wherein the hydroxyl group of the aromatic alcohol is connected to a non-aromatic ring carbon atom;

adding an aliphatic alcohol having from 1 to about 8 carbon atoms to the vessel in an amount from about 30 to about 58 parts;

adding a non-ionic thickener to the vessel; and

mixing the composition in the vessel, wherein the parts are based on 100 parts by weight of the composition, and wherein the composition is free of a cationic thickener.

47. The method according to claim 46, wherein the composition has a viscosity of from about 10 to about 100,000 centipoise, and wherein said aliphatic alcohol is methanol, ethanol, n-propanol, isopropyl alcohol, 2-methyl-2 propanol, hexanol, or combinations thereof.

48. The method according to claim 47, wherein the cationic substrate binding activity enhancing substance is present in an amount from about 0.03 to about 0.1 part, wherein said aromatic alcohol is present in an amount from about 0.75 to about 3.5 parts, and wherein the aliphatic alcohol is present in an amount from about 45 to about 58 parts.

49. The method according to claim 48, wherein the water is present in an amount from about 35 to about 50 parts.

50. The method according to claim 49, wherein the nonionic thickener is a cellulose-based thickener in an amount from about 0.1 to about 3.0 parts, and wherein the composition further includes a polyol, a skin conditioner, pH adjusters or combinations thereof.