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Glucose sensor and uses thereof

  • US 20070219346A1
  • Filed: 11/27/2006
  • Published: 09/20/2007
  • Est. Priority Date: 04/22/2002
  • Status: Abandoned Application
First Claim
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1. An isolated or purified recombinant human glucokinase polypeptide having decreased catalytic activity but a substantially identical ability to bind glucose relative to a corresponding wild-type human glucokinase. polypeptide, wherein said corresponding wild-type human glucokinase polypeptide has an amino acid sequence as set forth in GenBank Accession No. AAA52562, GenBank Accession No. AAA51824, GenBank Accession No. NP

  • 000153, GenBank Accession No. P35557;

    GenBank Accession No. AAB97681, GenBank Accession No. NP

    277042;

    GenBank Accession No. AAB97682, GenBank Accession No. NP

    277043;

    GenBank Accession No. AAB59563 or SEQ ID NO;

    2, or is encoded by a nucleotide sequence as set forth in GenBank Accession No. M90299, GenBank Accession No. M88011, GenBank Accession No. NM

    000162, GenBank Accession No. NM

    033507;

    GenBank Accession No. NM

    033508;

    GenBank Accession No. M69051, GenBank Accession No. AH005826 or SEQ ID NO;

    1;

    said recombinant human glucokinase polypeptide comprises an amino acid sequence that differs from the sequence of the corresponding wild-type human glucokinase polypeptide by a mutation at an amino acid residue corresponding to Asp 78, Ser 151, Asp 205, Arg 85, Lys 169, Gly 81, Lys 169, Thr 82, Asn83, Thr228, Ser 411, Lys 296, Ser 336, Thr332, Glu 290, Thr268, Glu256, Asn204, Asn231 or Lys269 of said corresponding wild-type human glucokinase polypeptide; and

    said recombinant human glucokinase polypeptide further comprises at least one affinity tag or reactive group for immobilizing said recombinant human glucokinase polypeptide onto a solid surface.

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