Automated analysis of a cardiac signal based on dynamical characteristics of the cardiac signal

• US 20070219453A1
• Filed: 03/14/2006
• Published: 09/20/2007
• Est. Priority Date: 03/14/2006
• Status: Active Grant

• Current Assignee: Braemar Incorporated
• Original Assignee: Cardionet Incorporated
• Inventors: Korzinov, Lev, Kremliovsky, Michael
• Granted Patent: US 7,729,753 B2
• Time in Patent Office: Days
• US Class Current: 600/509
• CPC Class Codes: A61B 5/349 Detecting specific parameters of the electrocardiograph cycle
• CPC Class Codes: A61B 5/361 Detecting fibrillation
• CPC Class Codes: A61B 5/7239 using differentiation including higher order derivatives

Abstract

Systems and techniques relating to locating cardiac wave forms in a cardiac signal, and to detecting a physiological condition, such as ventricular fibrillation. In general, in one aspect, a machine-implemented method includes obtaining a sensed cardiac signal of an organism, the sensed cardiac signal comprising a time series x(t); applying a Hilbert (H) transform to the time series x(t) to obtain H(x(t)), wherein x(t) and H(x(t)) together forming a partial state space trajectory; determining a speed of trajectory, for the sensed cardiac signal, from the partial state space trajectory; and identifying physiological information concerning the organism based on a combination of first and second signal elements, the first signal element including a phase property or an amplitude property of the speed of trajectory, and the second signal element including an amplitude property of the partial state space trajectory.

Claims

1. A machine-implemented method comprising:

obtaining a sensed cardiac signal of an organism, the sensed cardiac signal comprising a time series x(t);

applying a Hilbert (H) transform to the time series x(t) to obtain H(x(t)), wherein x(t) and H(x(t)) together forming a partial state space trajectory;

determining a speed of trajectory, for the sensed cardiac signal, from the partial state space trajectory; and

identifying physiological information concerning the organism based on a combination of first and second signal elements, the first signal element comprising a phase property or an amplitude property of the speed of trajectory, and the second signal element comprising an amplitude property of the partial state space trajectory.

2. The method of claim 1, further comprising separating a phase component of the speed of trajectory into a slow component and a fast component, wherein the first signal element comprises the phase property, the phase property being the slow component of the phase component.

3. The method of claim 1, wherein the determining comprises estimating the speed of trajectory in discrete time in a digital processor using finite differences in the partial state space trajectory, and the identifying comprises identifying the physiological information based on the phase property, the phase property being determined from the amplitude property of the speed of trajectory and a component of the speed of trajectory that corresponds to H(x(t)).

4. The method of claim 3, wherein the identifying comprises locating a P-wave center and boundaries based on the phase property and at least two thresholds.

5. The method of claim 3, wherein the identifying comprises locating a T-wave end based on change in the combination relative to a determined T-wave center, the combination being the phase property of the speed of trajectory multiplied by the amplitude property of the partial state space trajectory.

6. The method of claim 1, wherein the identifying the physiological information comprises locating a T-wave center in the sensed cardiac signal based on a momentum of trajectory derived from the amplitude property of the partial state space trajectory and the amplitude property of the speed of trajectory.

7. The method of claim 1, wherein the identifying the physiological information comprises estimating boundaries of a QRS complex in the sensed cardiac signal based on a momentum of trajectory derived from the amplitude property of the partial state space trajectory and the amplitude property of the speed of trajectory.

8. The method of claim 7, wherein estimating the boundaries of the QRS complex comprises locating a Q-point to the left of a maximum in the momentum of trajectory, and locating an S-point to the right of the maximum, based on a predefined portion of the maximum.

9. The method of claim 8, further comprising identifying an R-point based on the maximum in the momentum of trajectory.

10. The method of claim 1, wherein the identifying the physiological information comprises detecting ventricular fibrillation based on a momentum of trajectory derived from the amplitude property of the partial state space trajectory and the amplitude property of the speed of trajectory.

11. The method of claim 10, wherein detecting ventricular fibrillation comprises monitoring periodicity in oscillations of the momentum of trajectory.

12. The method of claim 10, wherein detecting ventricular fibrillation comprises:

maintaining a moving average of the momentum of trajectory; and

monitoring changes in the momentum of trajectory relative to the moving average.

13. A machine-readable medium encoding a computer program product operable to cause data processing apparatus to perform operations comprising:

obtaining a sensed cardiac signal of an organism, the sensed cardiac signal comprising a time series x(t);

applying a Hilbert (H) transform to the time series x(t) to obtain H(x(t)), wherein x(t) and H(x(t)) together forming a partial state space trajectory;

estimating a speed of trajectory, v(i), for the sensed cardiac signal, in discrete time t≡

i, i=[0 . . . n], using finite differences in the partial state space trajectory, wherein the estimated speed of trajectory v(i) includes a first component corresponding to x(t) and a second component corresponding to H(x(t));

determining from v(i), by division, a phase property of the estimated speed of trajectory v(i) in accordance with a trigonometric function of phase; and

identifying physiological information concerning the organism based on the phase property.

14. The machine-readable medium of claim 13, wherein the identifying comprises detecting wave form boundaries in the sensed cardiac signal.

15. The machine-readable medium of claim 14, wherein the detecting comprises detecting the wave form boundaries based on the phase property combined with an amplitude property of the partial state space trajectory.

16. The machine-readable medium of claim 13, wherein the trigonometric function is sine, and the determining comprises dividing the second component of v(i) by an absolute value of v(i).

17. The machine-readable medium of claim 13, wherein the trigonometric function is cosine, and the determining comprises dividing the first component of v(i) by an absolute value of v(i).

18. The machine-readable medium of claim 13, wherein the identifying comprises locating a P-wave center and boundaries using the phase property, an identified Q-point, and at least two thresholds.

19. The machine-readable medium of claim 16, the operations comprising locating a T-wave center using a momentum of trajectory derived from an amplitude property of the partial state space trajectory and an amplitude property of the speed of trajectory, and wherein the identifying comprises locating a T-wave end based on change in a value relative to the T-wave center, the value being the phase property of the estimated speed of trajectory multiplied by the amplitude property of the partial state space trajectory.

20. The machine-readable medium of claim 13, wherein the obtaining comprises receiving a real-time, electrocardiogram time series recorded previously for a human heart.

21. A cardiac monitoring apparatus comprising:

an input element;

a processor; and

a machine-readable medium encoding instructions operable to cause the processor to perform operations comprising;

obtaining, from the input element, a sensed cardiac signal of an organism;

applying a Hilbert transform to the sensed cardiac signal to form a partial state space trajectory;

determining a speed of trajectory, for the sensed cardiac signal, from the partial state space trajectory;

combining an amplitude property of the partial state space trajectory with an amplitude property of the speed of trajectory to form a calculated signal; and

identifying physiological information concerning the organism based on the calculated signal.

22. The apparatus of claim 21, wherein the combining comprises forming a calculated signal comprising a momentum of trajectory.

23. The apparatus of claim 22, wherein the identifying comprises detecting ventricular fibrillation based on the momentum of trajectory.

24. The apparatus of claim 22, wherein the identifying comprises locating Q and S points in a QRS complex of the sensed cardiac signal based on the momentum of trajectory.

25. The apparatus of claim 22, wherein the identifying comprises locating a T-wave center in the sensed cardiac signal based on the momentum of trajectory.

26. The apparatus of claim 22, wherein the calculated signal comprises a first calculated signal, the combining comprises forming a second calculated signal from a phase property of the speed of trajectory and the amplitude property of the partial state space trajectory, and the identifying comprises identifying the physiological information concerning the organism based on the first calculated signal and the second calculated signal.

27. The apparatus of claim 26, wherein the identifying comprises locating a T-wave end based on change in the second calculated signal relative to a T-wave center.

28. The apparatus of claim 26, wherein the operations comprise forming a third calculated signal from a phase property of the speed of trajectory;

and the identifying comprises identifying the physiological information concerning the organism based on the first calculated signal, the second calculated signal, and the third calculated signal.

29. The apparatus of claim 28, wherein the determining comprises estimating a speed of trajectory, v(i), for the sensed cardiac signal, in discrete time t≡

i, i=[0 . . . n], using finite differences in the partial state space trajectory, z(i);

the first calculated signal is calculated in accordance with |z(i)∥

v(i)|;

the second calculated signal is calculated in accordance with |z(i)|*Im(v(i))/|v(i)|; and

the third calculated signal is calculated in accordance with Im(v(i))/|v(i)| or Re(v(i))/|v(i)|.

30. The apparatus of claim 26, wherein the identifying comprises determining physiological quantities between identified boundaries and centers of wave modes including P-wave, QRS complex, and T-wave.

31. The apparatus of claim 30, wherein the determining comprises finding a first time difference between P-wave onset and Q-point (PR-interval), finding a second time difference between Q-point and S-point (QRS width), finding a third time difference between S-point and T-wave onset (ST segment), finding a fourth time difference between Q-point and T-wave offset (QT interval), finding a fifth time difference between S-point and a T-wave center (T-wave descend), finding a level of the sensed cardiac signal on the ST-segment, and finding a slope of the ST-segment in the sensed cardiac signal.