Dry Powder Drug Containment System Packages with Tabs, Inhalers and Associated Methods
First Claim
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1. A multi-dose drug containment system package adapted for use in an inhaler, comprising:
- a support member comprising a plurality of spaced apart drug compartments, each drug compartment having a sealant material detachably sealed thereto; and
a plurality of spaced apart tab members, a respective tab member attached to a portion of sealant material that extends over one or more drug compartments, wherein a respective tab member is operatively associated with at least one drug compartment so that, in operation, the respective tab member is configured to be grasped, such grasping causing the associated sealant material to pull away from at least one drug compartment to release a drug held therein.
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Abstract
Dry powder drug containment packages with tab members and meted dose sealed drug compartments can be used in an inhaler having a flow chamber with a hook member that opens the drug compartments and/or a portion that flexes to vibrate the dry powder to facilitate fluidic active dispersion for inhalation.
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Citations
74 Claims
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1. A multi-dose drug containment system package adapted for use in an inhaler, comprising:
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a support member comprising a plurality of spaced apart drug compartments, each drug compartment having a sealant material detachably sealed thereto; and
a plurality of spaced apart tab members, a respective tab member attached to a portion of sealant material that extends over one or more drug compartments, wherein a respective tab member is operatively associated with at least one drug compartment so that, in operation, the respective tab member is configured to be grasped, such grasping causing the associated sealant material to pull away from at least one drug compartment to release a drug held therein. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
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26. A dry powder inhaler comprising:
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an elongate chamber having opposing first and second end portions, a floor, and a ceiling with dry powder entry window, the first end portion merging into an inhaler mouth port and the second end portion merging into an air inlet port such that the mouth and air inlet ports are in fluid communication;
a vibrator operatively associated with a portion of the elongate chamber; and
a multi-dose dry powder package comprising a plurality of spaced apart discrete meted amounts of particulate dry powder in respective sealed drug compartments, wherein, in operation, at least one of the compartments is configured to align with the chamber entry window to release at least one meted amount of dry powder therein. - View Dependent Claims (27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50)
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51. A multi-dose dry powder inhaler, comprising:
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an inhaler having a housing body with a mouthpiece port and a spaced apart air inlet port disposed upstream thereof;
a multi-dose dry powder package held in the inhaler, the package comprising a plurality of spaced apart drug compartments with a meted amount of dry powder drug held therein, each compartment operatively associated with a tab member, held in the inhaler; and
a hook member disposed in the inhaler to translate between forward and rearward positions to engage a target tab member and pull thereon, thereby selectively pulling the associated floor sealant material off of at least one drug compartment during operation. - View Dependent Claims (52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64)
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65. A method of operating an inhaler, comprising;
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moving at least one drug compartment held on a dry powder package into a dispensing position above a dry powder entry window in an inhaler, the dry powder package having a plurality of sealed drug compartments, each having a meted amount of dry powder held captured therein above a releaseably attached floor sealant material;
engaging a tab extending generally downwardly from a portion of the floor sealant material;
pulling the tab to concurrently pull the floor sealant material off of at least one drug compartment;
releasing dry powder from the at least one drug compartment into a target inhalation flow path; and
vibrating the dry powder in the flow path. - View Dependent Claims (66, 67, 68, 69, 70, 71, 72, 73, 74)
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Specification