Apolipoprotein E genotyping and accompanying internet-based health management system

• US 20070224619A1
• Filed: 02/06/2007
• Published: 09/27/2007
• Est. Priority Date: 05/27/2003
• Status: Active Grant

• Current Assignee: Berkeley HeartLab, Inc. (Quest Diagnostics Incorporated)
• Original Assignee: Berkeley HeartLab, Inc. (Quest Diagnostics Incorporated)
• Inventors: Dhillon, Marshal, Visser, Henk, Hall, Christopher, Fleming, Adam, Schultz, Randon, Lanier, Vance, Banet, Matthew
• Granted Patent: US 7,842,506 B2
• Time in Patent Office: Days
• US Class Current: 435/6
• CPC Class Codes: C12Q 1/6883 for diseases caused by alterations of genetic material
• CPC Class Codes: C12Q 2600/156 Polymorphic or mutational markers
• CPC Class Codes: G01N 33/92 involving lipids, e.g. cholesterol , lipoproteins, or their receptors steroid hormones G01N33/743
• CPC Class Codes: G16B 20/00 ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
• CPC Class Codes: G16H 20/60 relating to nutrition control, e.g. diets
• CPC Class Codes: G16H 40/67 for remote operation

Abstract

The invention provides a system for monitoring a patient that includes: 1) a blood test that measures an Apo E genotype or a derivative thereof from the patient to generate Apo B information; 2) a database that receives and stores the patient'"'"'s Apo E information; and 3) an Internet-based system connected to the database and configured to process the Apo E information with an algorithm that, in response, generates a diet and treatment plan for the patient.

Claims

1. A system for monitoring a patient, comprising:

a blood test that measures an Apo E genotype or a derivative thereof from the patient to generate Apo E information;

a database that receives and stores the patient'"'"'s Apo E information;

an Internet-based system connected to the database and configured to process the Apo E information with an algorithm that, in response, generates a treatment plan for the patient.

2. The system of claim 1, wherein the treatment plan comprises a diet plan.

3. The system of claim 2, further comprising an algorithm that processes the Apo E information to generate a range of diet plans, each having a different amount of recommended fat calories.

4. The system of claim 1, further comprising a blood test that measures cholesterol or a derivative thereof to generate cholesterol information.

5. The system of claim 4, further comprising a blood test that measures a distribution of cholesterol.

6. The system of claim 5, further comprising a blood test that measures a distribution of LDL cholesterol.

7. The system of claim 4, wherein a database receives the cholesterol information, and the Internet-based system processes both the cholesterol and Apo E information to generate diet and treatment plans for the patient.

8. The system of claim 1, wherein the blood test determines an Apo E genotype.

9. The system of claim 8, wherein the algorithm processes the Apo E genotype to determine diet and exercise plans for the patient.

10. The system of claim 1, further comprising a website connected to the Internet-based system.

11. The system of claim 10, wherein the website is configured to display a treatment plan for the patient.

12. The system of claim 10, wherein the website comprises a first web interface that displays information for a single patient, and a second web interface that displays information for a group of patients.

13. The system of claim 1, further comprising a monitoring device that measures vital sign information from the patient.

14. The system of claim 13, further comprising an interface that receives vital sign information from the monitoring device and stores the vital sign information in a database.

15. The system of claim 14, wherein the vital sign information comprises at least one of blood pressure, weight, pulse oximetry, heart rate, temperature, glucose, and percent body fat.

16. The system of claim 1, further comprising a monitoring device that measures exercise information from the patient.

17. The system of claim 16, wherein the exercise information comprises at least one of steps, exercise time, calories burned, and vital signs measured during exercise.

18. A system for monitoring a patient, comprising:

a blood test that measures an Apo E genotype or a derivative thereof from the patient to generate Apo E information;

a monitoring device that measures vital sign information;

a database that receives and stores the patient'"'"'s Apo E information and vital sign information; and

an Internet-based system connected to the database and configured to process the Apo E information and vital sign information with an algorithm that, in response, generates a treatment plan for the patient.

19. A system for monitoring a patient, comprising:

a blood test that measures an Apo E genotype or a derivative thereof from the patient to generate Apo E information;

a monitoring device that measures vital sign information and exercise information;

a database that receives and stores the patient'"'"'s Apo E information, vital sign information, and exercise information; and

an Internet-based system connected to the database and configured to process the Apo E information, vital sign information, and exercise information with an algorithm that, in response, generates a treatment plan for the patient.

20. A system for monitoring a patient, comprising:

a first blood test that measures an Apo E genotype or a derivative thereof from the patient to generate Apo E information;

a second blood test that measures a distribution of cholesterol from a patient to generate cholesterol information;

a database that receives and stores the patient'"'"'s Apo E information and cholesterol information; and

an Internet-based system connected to the database and configured to process the Apo B information and cholesterol information with an algorithm that, in response, generates a treatment plan for the patient.

21. A system for monitoring a patient, comprising:

a first blood test that measures an Apo E genotype or a derivative thereof from the patient to generate Apo E information;

a second blood test that measures additional blood test information;

a database that receives and stores the patient'"'"'s Apo E information and cholesterol information; and

an Internet-based system connected to the database and configured to process the Apo E information and additional blood test information with an algorithm that, in response, generates a treatment plan for the patient.