Drug delivery means
First Claim
1. A chemical composition comprising:
- a plurality of cholesteryl esters arranged to form a vesicle.
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Accused Products
Abstract
The invention broadly comprises a chemical composition including a plurality of cholesteryl esters arranged to form a vesicle. In several embodiments, all of the plurality of cholesteryl esters have a same molecular length, which in some embodiments provides a vesicle having a generally smooth outer surface, while in other embodiments, a portion of the plurality of cholesteryl esters have different molecular lengths, which in some embodiments provides a vesicle having a generally irregular outer surface. In yet further embodiments, a shape of the vesicle is selected from the group consisting of spherical, oval, disc-like, tubular and polyhedral shapes, and in yet other embodiments, a wall of the vesicle is selected from the group consisting of a monolayer and a bilayer. In still further embodiments, the chemical composition further includes a polyethylene glycol coat of mixed polymer size. In some embodiments, the plurality of cholesteryl esters include at least two different cholesteryl esters, and in some of these embodiments, the at least two different cholesteryl esters are selected from the group consisting of: cholesteryl myristate, cholesteryl laurate, cholesteryl dodeconate, cholesteryl palmitate, cholesteryl arachidonate, cholesteryl behenate, cholesteryl linoleate, cholesteryl linolenate, cholesteryl oleate and cholesteryl stearate.
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Citations
20 Claims
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1. A chemical composition comprising:
a plurality of cholesteryl esters arranged to form a vesicle. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A method of delivering a drug to a cell comprising the steps of:
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a) combining a pharmaceutically effective amount of at least one drug with at least one cholestosome; and
,b) utilizing said at least one cholestosome to introduce said drug to the cell. - View Dependent Claims (14)
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15. A method of manufacturing at least one cholestosome comprising the steps of:
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a) mixing at least one cholesteryl ester in a first solvent to form a composition; b) mixing said composition of step a) with a second solvent until said at least one cholesteryl ester, said first solvent and said second solvent form a homogenous dispersion; and
,c) evaporating said first solvent leaving said at least one cholestosome in said second solvent.
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16. A method of manufacturing a drug delivery system comprising the steps of:
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a) mixing at least one cholesteryl ester in a first solvent to form a composition; b) mixing said composition of step a) and at least one drug in a pharmaceutically effective amount in a second solvent until said at least one cholesteryl ester, said first solvent, said at least one drug and said second solvent form a homogenous dispersion; and
,c) evaporating said first solvent leaving at least one cholestosome in said second solvent, wherein said at least one drug is combined with said at least one cholestosome. - View Dependent Claims (17, 18)
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19. A drug delivery system manufactured by the steps comprising:
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a) mixing at least one cholesteryl ester in a first solvent to form a composition; b) mixing said composition of step a) and at least one drug in a pharmaceutically effective amount in a second solvent until said at least one cholesteryl ester, said first solvent, said at least one drug and said second solvent form a homogenous dispersion; and
,c) evaporating said first solvent leaving at least one cholestosome in said second solvent, wherein said at least one drug is combined with said at least one cholestosome. - View Dependent Claims (20)
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Specification