TREATMENT OF VITILIGO BY MICROPORE DELIVERY OF CELLS
First Claim
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7-1. The method of claim 1, wherein the at least one cell is a melanocyte, a melanoblast, a stem cell, or combinations thereof.
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Abstract
Methods, compositions and apparatus for restoring pigmentation to skin that has suffered pigment loss are described. The methods include creating a plurality of spaced-apart microchannels or voids in the skin and depositing into the micropore channels or voids a composition comprising at least one cell capable of producing melanin, a growth factor, and, optionally, a scaffolding material, a differentiation factor, a proliferation factor, and/or a pigment. Alternatively, a composition comprising a pigment can be deposited into the micropore channels or voids to restore pigmentation to the skin.
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Citations
57 Claims
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7-1. The method of claim 1, wherein the at least one cell is a melanocyte, a melanoblast, a stem cell, or combinations thereof.
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8-2. The method of claim 1, wherein the at least one cell is a melanocyte.
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23. An apparatus for treating or preventing loss of pigmentation in the skin of a subject in need thereof, the apparatus comprising:
a handpiece movable over skin wherein the handpiece is arranged to receive an optical beam and focus the optical beam at a plurality of spaced-apart locations on the skin thereby creating a plurality of micropore channels or voids in the skin for the deposition of a composition, wherein the composition comprises at least one cell capable of producing melanin and a growth media. - View Dependent Claims (24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55)
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56. A method of treating loss of pigmentation in the skin of a subject in need thereof, the method comprising:
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irradiating skin with laser irradiation to form a plurality of micropore channels or voids, wherein the micropore channels or void extend into the basal layer of the epidermis; and
implanting a composition into the micropore channels or voids, wherein the composition comprises a pigment. - View Dependent Claims (57)
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Specification