Composite vascular prosthesis

• US 20070225795A1
• Filed: 03/24/2007
• Published: 09/27/2007
• Est. Priority Date: 03/24/2006
• Status: Abandoned Application

• Current Assignee: Juan Granada, Simon M. Furnish
• Original Assignee: Juan Granada, Simon M. Furnish
• Inventors: Furnish, Simon M., Granada, Juan
• Application Number:
  US11/726,986
• Publication Number:
  US 20070225795A1
• Time in Patent Office: Days
• US Class Current: 623/1.150
• CPC Class Codes: A61F 2/91 made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
• CPC Class Codes: A61F 2210/0076 multilayered, e.g. laminated structures
• CPC Class Codes: A61F 2220/005 using adhesives
• CPC Class Codes: A61F 2220/0075 sutured, ligatured or stitched, retained or tied with a rope, string, thread, wire or cable
• CPC Class Codes: A61F 2250/003 differing in adsorbability or resorbability, i.e. in adsorption or resorption time
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body

Abstract

A novel treatment for atherosclerotic vascular disease is described utilizing the implantation of a thin, conformable biocompatible prosthesis constructed from a composite of various structural and therapeutic scaffolds in combination with one or more bioactive agents. This prosthesis can be delivered into position over a lesion in order to passivate atherosclerotic plaques with minimal remodeling of the artery, or alternatively can be applied with a balloon to passivate the remodeled site. The composite prosthesis itself provides mild structural reinforcement of the vessel wall and an evenly distributed platform for the introduction of bioactive therapeutic agents.

Claims

1. An expandable vascular prosthesis, comprising:

an at least substantially tubular, radially expandable structural component comprising an abluminal surface and an adluminal surface; and

an adhesive coating comprising at least one molecule selected from the group consisting of a collagen and an elastin, wherein the adhesive coating is disposed on at least part of the abluminal surface of the structural component, and

wherein the adluminal surface comprises surface features having depths in the range of 5 nm to 5 μ

m and lateral dimensions in the range of 50 nm to 5 microns, said surface features being present on the adluminal surface at a density of 1 to 500 surface features per 10 μ

m².

2. The prosthesis of claim 1, wherein at least part of the adluminal surface is coated with at least one biomolecule.

3. The prosthesis of claim 2, wherein the at least one biomolecule coated on the adluminal surface comprises a fibronectin.

4. The prosthesis of claim 1, wherein the bioadhesive coating comprises an activatable protein crosslinker.

5. The prosthesis of claim 1, wherein the prosthesis is self-expanding.

6. The prosthesis of claim 1, wherein the structural component is metallic.

7. The prosthesis of claim 1, wherein the structural component is polymeric.

8. The prosthesis of claim 1, wherein the prosthesis exerts a radial expansion force in the range of 30 to 750 mm Hg in a radially expanded state.

9. The prosthesis of claim 8, wherein the prosthesis exerts a radial expansion force in the range of 30 to 250 mm Hg in a radially expanded state.

10. The prosthesis of claim 1, wherein the structural component has a wall thickness in the range of 20-100 microns.

11. The prosthesis of claim 1, wherein the adluminal surface comprises surface features having depths in the range of 5 nm to 200 nm

12. A method for treating an atherosclerotic lesion in a blood vessel of a patient, comprising the steps of:

locating a site of an atherosclerotic lesion in a blood vessel of a patient;

transporting a prosthesis according to claim 1 in an unexpanded state to the site of the atherosclerotic lesion in the blood vessel; and

radially expanding the prosthesis at the site of the atherosclerotic lesion so that the prosthesis contacts the blood vessel at the site.

13. The method of claim 12, wherein the atherosclerotic lesion is a vulnerable plaque.

14. The method of claim 12, wherein the atherosclerotic lesion is an atherosclerotic lesion freshly treated by angioplasty.

15. The method of claim 12, further comprising the step of:

crosslinking the bioadhesive coating of the prosthesis to the blood vessel.

16. The method of claim 15, wherein the bioadhesive coating of the prosthesis further comprises an activatable crosslinker and the step of crosslinking the bioadhesive layer of the prosthesis to the blood vessel comprises activating the activatable crosslinker.

17. A radially expandable vascular luminal prosthesis, comprising:

a structural component;

an adhesive abluminal surface; and

an endothelial cell-promoting adluminal surface.

18. The prosthesis of claim 17, wherein the prosthesis exerts a radial expansion force in the range of 30 to 750 mm Hg in a radially expanded state.

19. The prosthesis of claim 18, wherein the prosthesis exerts a radial expansion force in the range of 30 to 250 mm Hg in a radially expanded state.

20. The prosthesis of claim 17, wherein the adhesive abluminal surface is conditionally adhesive.

21. The prosthesis of claim 17, wherein the adhesive abluminal surface comprises at least one protein providing adhesiveness of the prosthesis to a blood vessel wall.

23. The prosthesis of claim 17, wherein the adluminal surface comprises endothelial cell-promoting molecules.

24. The prosthesis of claim 17, wherein the prosthesis comprises an abluminal layer that presents the adhesive abluminal surface.

25. The prosthesis of claim 17, wherein the prosthesis comprises an adluminal layer that presents the endothelial cell-promoting adluminal surface.

22. The prosthesis of clam 17, wherein the adluminal surface comprises endothelial cell-promoting structural features.