Composite vascular prosthesis
First Claim
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1. An expandable vascular prosthesis, comprising:
- an at least substantially tubular, radially expandable structural component comprising an abluminal surface and an adluminal surface; and
an adhesive coating comprising at least one molecule selected from the group consisting of a collagen and an elastin, wherein the adhesive coating is disposed on at least part of the abluminal surface of the structural component, andwherein the adluminal surface comprises surface features having depths in the range of 5 nm to 5 μ
m and lateral dimensions in the range of 50 nm to 5 microns, said surface features being present on the adluminal surface at a density of 1 to 500 surface features per 10 μ
m2.
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Abstract
A novel treatment for atherosclerotic vascular disease is described utilizing the implantation of a thin, conformable biocompatible prosthesis constructed from a composite of various structural and therapeutic scaffolds in combination with one or more bioactive agents. This prosthesis can be delivered into position over a lesion in order to passivate atherosclerotic plaques with minimal remodeling of the artery, or alternatively can be applied with a balloon to passivate the remodeled site. The composite prosthesis itself provides mild structural reinforcement of the vessel wall and an evenly distributed platform for the introduction of bioactive therapeutic agents.
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Citations
25 Claims
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1. An expandable vascular prosthesis, comprising:
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an at least substantially tubular, radially expandable structural component comprising an abluminal surface and an adluminal surface; and an adhesive coating comprising at least one molecule selected from the group consisting of a collagen and an elastin, wherein the adhesive coating is disposed on at least part of the abluminal surface of the structural component, and wherein the adluminal surface comprises surface features having depths in the range of 5 nm to 5 μ
m and lateral dimensions in the range of 50 nm to 5 microns, said surface features being present on the adluminal surface at a density of 1 to 500 surface features per 10 μ
m2. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. A radially expandable vascular luminal prosthesis, comprising:
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a structural component; an adhesive abluminal surface; and an endothelial cell-promoting adluminal surface. - View Dependent Claims (18, 19, 20, 21, 23, 24, 25)
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22. The prosthesis of clam 17, wherein the adluminal surface comprises endothelial cell-promoting structural features.
Specification