BIOMEDICAL DEVICES CONTAINING INTERNAL WETTING AGENTS
First Claim
Patent Images
5. The hydrogel of claim 5 wherein said at least one siloxane containing macromers is formed via polymerizing said siloxane group with at least one acrylic or methacrylic compound.
1 Assignment
0 Petitions
Accused Products
Abstract
This invention includes a wettable biomedical device containing a high molecular weight hydrophilic polymer and a hydroxyl-functionalized silicone-containing monomer.
79 Citations
130 Claims
- 5. The hydrogel of claim 5 wherein said at least one siloxane containing macromers is formed via polymerizing said siloxane group with at least one acrylic or methacrylic compound.
- 9. (canceled)
-
14-18. -18. (canceled)
-
23. (canceled)
-
30. (canceled)
-
31. (canceled)
-
34. (canceled)
-
38. (canceled)
-
40. (canceled)
-
45. (canceled)
-
48. (canceled)
-
49. (canceled)
- 50. A method comprising the steps of (a) mixing reactive components comprising at least one high molecular weight hydrophilic polymer, at least one siloxane containing macromer and an effective amount of at least one compatibilizing component and (b) curing the product of step (a) to form a biomedical device.
- 102. A method comprising the steps of (a) mixing reactive components comprising a high molecular weight hydrophilic polymer and an effective amount of a compatibilizing component and (b) curing the product of step (a) at or above a minimum gel time, to form a wettable biomedical device.
- 118. A method for improving the wettability of an ophthalmic device formed from a reaction mixture comprising adding at least one high molecular hydrophilic weight polymer and a compatibilizing effective amount of at least one compatibilizing component to said reaction mixture, wherein said compatibilizing component is not a styrene functionalized prepolymer made from hydroxyl functional methacrylates.
-
124. An ophthalmic lens comprising a silicone hydrogel which has, without surface treatment, a tear film break up time of at least about 7 seconds
-
125. A silicone hydrogel contact lens comprising at least one oxygen permeable component, at least one compatibilizing component and an amount of high molecular weight hydrophilic polymer sufficient to provide said device, without a surface treatment, with tear film break up time after about one day of wear of at least about 7 seconds.
-
126. A device comprising a silicone hydrogel contact lens which is substantially free from surface deposition without surface modification.
-
127. A wettable silicone hydrogel comprising the reaction product of at least one siloxane containing macromer;
-
at least one high molecular weight hydrophilic polymer; and
at least one compatibilizing component selected from the group consisting of (3-methacryloxy-2-hydroxypropyloxy)propylbis(trimethylsiloxy)methylsilane, (3-methacryloxy-2-hydroxypropyloxy)propyltris(tri methylsiloxy)silane, bis-3-methacryloxy-2-hydroxypropyloxypropyl polydimethylsiloxanes, 3-methacryloxy-2-(2-hydroxyethoxy)propyloxy)propyl bis (trimethylsiloxy)methylsilane, N-2-methacryloxyethyl-O-(methyl-bis-tri methylsiloxy-3-propyl)silyl carbamate, N,N,N′
,N′
-tetrakis(3-methacryloxy-2-hydroxypropyl)-α
,ω
-bis-3-aminopropyl-polydimethylsiloxane and mixtures thereof, wherein said compatibilizing component is present in an amount effective to compatibilize said at least one siloxane-containing macromer and said at least one high molecular weight hydrophilic polymer. - View Dependent Claims (1, 2, 3, 4, 7, 12, 13, 19, 20, 21, 22, 24, 25, 26, 27, 28, 29, 32, 33, 35, 36, 41, 42, 43, 44, 46, 47, 130)
-
-
128. A wettable silicone hydrogel comprising the reaction product of
at least one siloxane containing macromer; at least one high molecular weight hydrophilic polymer; and
at least one compatibilizing component comprising mono-(3-methacryloxy-2-hydroxypropyloxy)propyl terminated, mono-butyl terminated polydimethylsiloxane.- View Dependent Claims (8, 37, 39, 129)
Specification