Methods and compositions for deterring abuse of orally administered pharmaceutical products
First Claim
Patent Images
1. A therapeutic pharmaceutical composition comprising (a) an opioid analgesic;
- (b) a gel forming polymer;
(c) a nasal tissue irritant having a slight amount or greater degree of irritancy; and
(d) a flushing agent in sufficient amount to cause flushing if greater than a prescribed amount of the analgesic of the therapeutic composition is ingested.
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Accused Products
Abstract
This invention relates to an abuse deterrent formulation of an oral dosage form of a therapeutically effective amount of any active drug substance that can be subject to abuse combined with a gel forming polymer, a nasal mucosal irritating surfactant and a flushing agent. Such a dosage form is intended to deter abuse of the active drug substance via injection, nasal inhalation or consumption of quantities of the dosage unit exceeding the usual therapeutically effective dose.
183 Citations
20 Claims
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1. A therapeutic pharmaceutical composition comprising
(a) an opioid analgesic; -
(b) a gel forming polymer;
(c) a nasal tissue irritant having a slight amount or greater degree of irritancy; and
(d) a flushing agent in sufficient amount to cause flushing if greater than a prescribed amount of the analgesic of the therapeutic composition is ingested. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A therapeutic pharmaceutical composition comprising
(a) an analgesic; -
(b) a gel forming polymer;
(c) a mucosal tissue irritant comprising one or more of a foaming agent, anti-foaming agent, dispersant, emulsifier, solubilizer, emollient, gel enhancer, detergent, chelating agent and wetting agent; and
(d) a flushing agent in sufficient amount to cause flushing if greater than a prescribed amount of the analgesic of the therapeutic composition is ingested.
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13. A therapeutic pharmaceutical composition comprising
(a) an opioid analgesic; -
(b) means for blocking one or more of the sphenoid, maxillary, ethmoid and frontal sinuses;
(c) a nasal tissue irritant; and
(d) a flushing agent in sufficient amount to cause flushing if greater than a prescribed amount of the analgesic of the therapeutic composition is ingested. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20)
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Specification