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Methods of treating inflammatory and autoimmune diseases with natalizumab

  • US 20070231319A1
  • Filed: 03/02/2007
  • Published: 10/04/2007
  • Est. Priority Date: 03/03/2006
  • Status: Abandoned Application
First Claim
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1. A method of treating a patient with an inflammatory or autoimmune disease with natalizumab comprising:

  • (a) administering a dose of natalizumab for a first dosage period;

    (b) monitoring the amount of bivalent natalizumab in the patient'"'"'s plasma or serum during the first dosage period;

    (c) determining a second dose of natalizumab based on the level of bivalent natalizumab observed; and

    (d) administering a second dose of natalizumab for a second dosage period;

    wherein the second dose improves the safety and/or efficacy of the treatment during the second dosage period.

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