Methods of predicting behavior of cancers
First Claim
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1. A method of diagnosing prostate cancer in a subject comprising detecting elevated levels of Hedgehog (Hh) pathway activity in cells from the subject, as compared with corresponding normal cells.
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Abstract
Elevated Hedgehog (Hh) pathway activity, including ligand stimulated Hh pathway activity, was detected in prostate tumors, and determined to be associated with growth and proliferation of the cancer cells. Accordingly, methods are provided for treating a prostate cancer associated with elevated Hh pathway activity by reducing or inhibiting the Hh pathway activity. Also provided are methods of identifying a prostate tumor of a subject as, or as capable of becoming lethal and/or metastatic.
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25 Claims
- 1. A method of diagnosing prostate cancer in a subject comprising detecting elevated levels of Hedgehog (Hh) pathway activity in cells from the subject, as compared with corresponding normal cells.
- 9. A method of identifying a subject at risk of recurrence of prostate cancer comprising detecting elevated levels of Hedgehog (Hh) pathway activity in prostate cells from the subject as compared with corresponding normal cells.
- 18. A method of identifying a prostate tumor of a subject as, or as capable of becoming, lethal and/or metastatic, comprising detecting elevated levels of Hedgehog (Hh) pathway activity as compared with corresponding normal cells.
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