Method and system for determining whether a drug will be effective on a patient with a disease
First Claim
1. A method of determining whether a patient will be responsive to a drug or treatment, the method comprising:
- obtaining a test spectrum produced by a mass spectrometer from a serum produced from a patient having a disease;
processing the test spectrum to determine a relation to a group of class labeled spectra produced from respective serum from other patients having a same or similar clinical stage disease and known to have responded to or not responded to a drug or treatment; and
determining, based on the relation of the test spectrum to the group of class labeled spectra, whether the patient will be responsive to the drug or treatment.
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Accused Products
Abstract
A process of determining whether a patient with a disease or disorder will be responsive to a drug, used to treat the disease or disorder, including obtaining a test spectrum produced by a mass spectrometer from a serum produced from the patient. The test spectrum may be processed to determine a relation to a group of class labeled spectra produced from respective serum from other patients having the or similar clinical stage same disease or disorder and known to have responded or not responded to the drug. Based on the relation of the test spectrum to the group of class labeled spectra, a determination may be made as to whether the patient will be responsive to the drug.
70 Citations
57 Claims
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1. A method of determining whether a patient will be responsive to a drug or treatment, the method comprising:
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obtaining a test spectrum produced by a mass spectrometer from a serum produced from a patient having a disease; processing the test spectrum to determine a relation to a group of class labeled spectra produced from respective serum from other patients having a same or similar clinical stage disease and known to have responded to or not responded to a drug or treatment; and determining, based on the relation of the test spectrum to the group of class labeled spectra, whether the patient will be responsive to the drug or treatment. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. A system for determining whether a patient will be responsive to a drug or treatment, the system comprising:
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a storage device configured to store a test spectrum produced by a mass spectrometer from a serum produced from a patient having a disease and a group of class labeled spectra produced from respective serum from other patients having a same or similar clinical stage disease and known to have responded or not responded to a drug or treatment; and a processor in communication with the storage device, the processor executing software to; obtain a test spectrum produced by a mass spectrometer from a serum produced from a patient having a disease; process the test spectrum to determine a relation to a group of class labeled spectra produced from respective serum from other patients having the same or similar disease and known to have responded or not responded to a drug or treatment; and determine, based on the relation of the test spectrum to the group of class labeled spectra, whether the patient will be responsive to the drug or treatment. - View Dependent Claims (22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39)
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40. A system of determining whether a patient will be responsive to a drug or treatment, the system comprising:
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means for obtaining a test spectrum produced by a mass spectrometer from a serum produced from a patient having a disease; means for processing the test spectrum to determine a relation to a group of class labeled spectra produced from respective serum from other patients having the same or similar clinical stage disease and known to have responded or not responded to a drug or treatment; and means for determining, based on the relation of the test spectrum to the group of class labeled spectra, whether the patient will be responsive to the drug or treatment. - View Dependent Claims (41, 42, 43, 44, 45)
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46. A method of determining whether a patient will be responsive to a drug or treatment, the method comprising:
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obtaining a test spectrum having a plurality of features produced by a mass spectrometer from a serum produced from a patient having a disease; processing the features of the test spectrum to determine if a relation exists between the test spectrum and a group of class labeled spectra having differentiating peaks produced from respective serum from other patients having the same or similar clinical stage disease as the patient and known to have responded to or not responded to a drug or treatment; and determining, based on the processed peaks of the test spectrum, whether the patient will be responsive to the drug or treatment. - View Dependent Claims (47, 48, 49, 50, 51, 57)
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52. A system for determining whether a patient will be responsive to a drug or treatment, the system comprising:
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a storage device configured to store a test spectrum produced by a mass spectrometer from a serum produced from a patient having a disease and a group of class labeled spectra produced from respective serum from other patients having the same or similar clinical stage disease as the patient and known to have responded or not responded to a drug or treatment; and a processor in communication with the storage device, the processor executing software to; obtain a test spectrum having a plurality of features; processing the features of the test spectrum to determine if a relation exists between the test spectrum and a group of class labeled spectra having differentiating peaks produced from respective serum from other patients having a same or similar clinical stage disease and known to have responded to or not responded to a drug or treatment; and determine, based on the processed peaks of the test spectrum, whether the patient will be responsive to the drug or treatment. - View Dependent Claims (53, 54, 55, 56)
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Specification