Pharmaceutical Composition And Method For Treating Neurodegenerative Disorders
First Claim
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1. A unit dosage form comprising a combination of (R)-2-(2-fluoro-4-biphenylyl)propionic acid or a pharmaceutically acceptable salt or ester thereof and an acetylcholine esterase inhibitor or a pharmaceutically acceptable salt or ester thereof.
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Abstract
The invention provides compositions and methods for treating neurodegenerative disorders. The method of the invention involves administering to an individual in need of treatment a composition having an acetylcholine esterase inhibitor and another therapeutic agent. The methods and compositions of the invention are useful for treating and preventing neurodegenerative disorders like Alzheimer'"'"'s disease, dementia, and mild cognitive impairment.
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Citations
25 Claims
- 1. A unit dosage form comprising a combination of (R)-2-(2-fluoro-4-biphenylyl)propionic acid or a pharmaceutically acceptable salt or ester thereof and an acetylcholine esterase inhibitor or a pharmaceutically acceptable salt or ester thereof.
- 11. A method of treating mild Alzheimer'"'"'s disease in an individual comprising identifying an individual having mild Alzheimer'"'"'s disease and administering to the individual an Alzheimer'"'"'s disease treating effective amount of (R)-2-(2-fluoro-4-biphenylyl)propionic acid or a pharmaceutically acceptable salt or ester thereof and an acetylcholine esterase inhibitor or a pharmaceutically acceptable salt or ester thereof.
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13. The method of 12 wherein donepezil and (R)-2-(2-fluoro-4-biphenylyl)propionic acid are co-formulated.
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23. A co-formulation comprising a first compound which is donepezil or a pharmaceutically acceptable salt or ester thereof and a second compound which is an Aβ
- 42 lowering agent or a pharmaceutically acceptable salt or ester thereof.
- View Dependent Claims (24, 25)
Specification