System and method for imaging the reflectance of a substrate
First Claim
1. A system for imaging the reflectance of a substrate, comprising;
- a light source;
a light transport body configured to project light from the light source to an examination substrate and transmit light reflected by the examination substrate;
an analysis section in optical communication with the light transport body and having a reflectance avoidance imaging module and at least one of a reflectance spectrophotometry module and a fluorescence imaging module.
2 Assignments
0 Petitions
Accused Products
Abstract
The present application discloses a system and method for the comprehensive monitoring of the microcirculation in order to assess the ultimate efficacy of the cardiovascular system in delivering adequate amounts of oxygen to the organ cells. The system utilizes reflectance avoidance by reflectance filtering, such as OPS imaging or Mainstream Dark Field imaging, or by Sidestream Dark Field imaging, which utilizes external direct light on the tip of the light guide to achieve reflectance avoidance whereby incident and reflected light do not travel down the same pathway. The system can combine reflectance avoidance with other imaging modalities to provide information regarding profusion, oxygen saturation and oxygen availability. The system can image the reflectance of a substrate and may include a light source, a light transport body configured to project light from the light source to an examination substrate and transmit light reflected by the examination substrate, and an analysis section in optical communication with the light transport body and having a reflectance avoidance imaging module and at least one of a reflectance spectrophotometry module and a fluorescence imaging module. The method may include utilizing the microcirculatory flow information, the oxygen availability information, and the adequacy of oxygenation of tissue cells information, making an early and sensitive determination regarding states of shock, such as septic, hypovolemic, cardiogenic and obstructive septic shock, in patients, and guiding resuscitation therapies aimed at correcting this condition.
166 Citations
35 Claims
-
1. A system for imaging the reflectance of a substrate, comprising;
-
a light source;
a light transport body configured to project light from the light source to an examination substrate and transmit light reflected by the examination substrate;
an analysis section in optical communication with the light transport body and having a reflectance avoidance imaging module and at least one of a reflectance spectrophotometry module and a fluorescence imaging module. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
-
-
10. A system for imaging the reflectance of a substrate, comprising;
-
a light source;
a light transport body configured to project light from the light source along one or more illumination passages formed within the light transport body to an examination substrate and transmit light reflected by the examination substrate along an imaging passage which is optically isolated from the one or more illumination passages;
an analysis section in optical communication with the light transport body and comprising a reflectance avoidance imaging module. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
-
-
24. A method of imaging the reflectance of a substrate, comprising:
-
illuminating an examination substrate with light;
analyzing the light reflected by the examination substrate with a reflectance spectrophotometer;
determining a concentration of hemoglobin within the examination substrate based on a spectral characteristic of the examination substrate with the reflectance spectrophotometer;
analyzing the light reflected by the examination substrate with a reflectance avoidance imaging module; and
measuring a flow through a vessel within the examination substrate within a reflectance avoidance imaging module. - View Dependent Claims (25, 26)
-
-
27. A method of comprehensively monitoring the microcirculation of a patient, comprising:
-
illuminating a tissue substrate;
avoiding the reflection of light from the surface of the tissue substrate;
receiving light from the tissue substrate;
utilizing some of the received light to image microcirculatory flow in the tissue substrate;
utilizing some of the received light to determine oxygen availability in the microcirculation; and
utilizing some of the received light to determine the adequacy of oxygenation of the tissue cells. - View Dependent Claims (28, 29, 30, 31, 32, 33, 34, 35)
-
Specification