Hyperspectral Imaging in Diabetes and Peripheral Vascular Disease
First Claim
Patent Images
1. A medical instrument comprising:
- a first stage optic responsive to illumination of tissue;
a spectral separator;
one or more polarizers;
an imaging sensor;
a diagnostic processor;
a filter control interface;
a general purpose operating module to assess the state of tissue in diabetic subjects following a set of instructions, and a calibrator.
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Abstract
The invention is directed to methods and systems of hyperspectral and multispectral imaging of medical tissues. In particular, the invention is directed to new devices, tools and processes for the detection and evaluation of diseases and disorders such as, but not limited to diabetes and peripheral vascular disease, that incorporate hyperspectral or multispectral imaging.
80 Citations
24 Claims
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1. A medical instrument comprising:
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a first stage optic responsive to illumination of tissue;
a spectral separator;
one or more polarizers;
an imaging sensor;
a diagnostic processor;
a filter control interface;
a general purpose operating module to assess the state of tissue in diabetic subjects following a set of instructions, and a calibrator. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A method for assessing the state of tissue of a diabetic subject comprising:
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preprocessing hyperspectral information;
building a visual image;
defining a region of interest in tissue;
converting the visual image into units of optical density by taking a negative logarithm of each decimal base;
decomposing a spectra for each pixel into several independent components;
determining three planes for an RGB pseudo-color image;
determining a sharpness factor plane;
converting the RGB pseudo-color image to a hue-saturation-value/intensity image having a plane;
adjusting the hue-saturation-value/intensity image plane with the sharpness factor plane;
converting the hue-saturation-value/intensity image back to the RGB pseudo-color image;
removing outliers beyond a standard deviation and stretching image between 0 and 1;
displaying the region of interest in pseudo-colors; and
characterizing a metabolic state of the tissue of interest. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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Specification