Handheld apparatus to deliver active agents to biological interfaces

• US 20070232983A1
• Filed: 08/30/2006
• Published: 10/04/2007
• Est. Priority Date: 09/30/2005
• Status: Abandoned Application

• Current Assignee: TTI Ellebeau, Inc. (Ease Asset Management Ltd.)
• Original Assignee: TTI Ellebeau, Inc. (Ease Asset Management Ltd.)
• Inventors: Smith, Gregory
• Application Number:
  US11/514,296
• Publication Number:
  US 20070232983A1
• Time in Patent Office: Days
• US Class Current: 604/20
• CPC Class Codes: A61N 1/0436 Material of the electrode
• CPC Class Codes: A61N 1/0444 Membrane
• CPC Class Codes: A61N 1/0448 Drug reservoir

Abstract

A device to deliver an active agent to a biological entity includes a handle shaped portion configured to be grasped to provide a first portion of the biological entity, and a probe shaped portion extending from the handle shaped portion configured to be positioned on or proximate a second portion of the biological entity to complete a circuit path from a power source through the biological entity. The device may employ iontophoresis. The device may be configured to approximate the shape of a conventional toothbrush or electric tooth brush.

Claims

1. A device for delivering an active agent under the influence a power source to a biological entity, the device comprising:

a handle sized and dimensioned to be grasped;

a plurality of probes extending from the handle;

a counter electrode assembly at least partially positioned in the handle, the counter electrode assembly comprising at least a counter electrode element operable to supply an electrical potential of a first polarity, the counter electrode assembly operable to provide an electrically conductive path between a first biological interface and the counter electrode element when the handle is grasped; and

at least one active electrode assembly positioned proximate the plurality of probes, the active electrode assembly comprising at least one active electrode element operable to supply an electrical potential of a second polarity different than the first polarity, the active electrode assembly operable to provide an electrically conductive path between a second biological interface and the active electrode element when the probes are placed proximate the second biological interface, where the first and the second biological interfaces are each part of the biological entity, and wherein at least some of the active agent is positioned between the at least one active electrode element and an exterior of the each of the probes.

2. The device of claim 1 wherein the active agent comprises strontium.

3. The device of claim 2 wherein the active electrode element comprises silver.

4. The device of claim 2 wherein the active electrode element comprises a compound of silver chloride.

5. The device of claim 1 wherein the active agent comprises strontium chloride.

6. The device of claim 1 wherein the active agent comprises fluoride.

7. The device of claim 1 wherein the active electrode assembly has at least one receptacle formed therein, sized to removably receive the active agent formed as an insert.

8. The device of claim 7, further comprising:

the active agent formed as the insert.

9. The device of claim 8 wherein the insert comprises the active agent in a gel form.

10. The device of claim 1 wherein the active electrode assembly further comprises an outermost ion selective membrane positioned such that the outermost ion exchange membrane is between the active electrode and the first biological interface the when in use, and an electrolyte positioned between the active electrode element and the outermost ion selective membrane.

11. The device of claim 10 wherein the outermost ion selective membrane is an ion exchange membrane permselective to ions of the second polarity;

and further comprising;

an inner ion selective membrane positioned between the electrolyte and the outermost ion selective membrane, wherein the inner ion selective membrane is an ion exchange membrane permselective to ions of the first polarity.

12. The device of claim 11, further comprising:

the power source having a first pole and a second pole, the first pole electrically coupled to the counter electrode element and the second pole electrically coupled to the active electrode element.

13. An iontophoresis device to deliver an active agent to a biological entity by forming a circuit path from a power source via two different portions of the biological entity, the iontophoresis device comprising:

a handle having a perimeter sized and configured to be grasped;

a counter electrode assembly at least partially received in the handle portion of the housing, the counter electrode assembly comprising a counter electrode element operable to supply an electrical potential of a first polarity from a power source; and

at least one active electrode assembly including a plurality of probes, at least one active electrode element, and at least one active agent reservoir, each of the plurality of probes extending from the handle and having an exterior that is distinct from one another, the at least one active agent reservoir being positioned between the at least one active electrode element and the exterior the probes, the at least one active electrode element operable to supply an electrical potential of a second polarity, opposite to the first polarity to the active agent reservoir such that at least some active agent is driven from the active agent reservoir through the exterior of the probes in response to the supply of the electrical potential of the second polarity.

14. The iontophoresis device of claim 13 wherein the active electrode element comprises a quantity of silver and wherein the active electrode assembly further comprises:

a strontium chloride active agent positioned to be delivered to a first portion of the biological entity when the active electrode element is electrically coupled to a second pole of the power source, the counter electrode is electrically coupled to a first pole of the power source and the counter electrode assembly is positioned at least proximate the second portion of the biological entity.

15. The iontophoresis device of claim 13 wherein the active electrode assembly further comprises:

a strontium chloride active agent positioned to be delivered at least proximate a tooth of the biological entity when the active electrode element is electrically coupled to a second pole of the power source, the counter electrode is electrically coupled to a first pole of the power source and the counter electrode assembly is positioned a hand of the biological entity while the handle portion is grasped by the biological entity.

16. The iontophoresis device of claim 15 wherein the strontium chloride active agent is stored in at least one of the active agent reservoirs, selectively insertable in the active electrode assembly.

17. The iontophoresis device of claim 15 wherein the strontium chloride active agent is formed as a number of gel type active agent reservoirs, selectively insertable in the active electrode assembly.

18. The iontophoresis device of claim 13 wherein the active electrode assembly further comprises:

an outermost ion selective membrane positioned in the probe to be proximate one of the portions of the biological entity when in use, and an active agent cached in the outermost ion selective membrane.

19. The iontophoresis device of claim 18 wherein the outermost ion selective membrane is an ion exchange membrane substantially selectively permeable by ions of the second polarity and substantially non-permeable to ions of the first polarity.

20. The iontophoresis device of claim 13 wherein the active electrode assembly further comprises:

a fluoride active agent positioned to be delivered at least proximate a tooth of the biological entity when the active electrode element is electrically coupled to a second pole of the power source, the counter electrode is electrically coupled to a first pole of the power source and the counter electrode assembly is positioned a hand of the biological entity while the handle portion is grasped by the biological entity.

21. The iontophoresis device of claim 13 wherein each of the probes has a perimeter smaller than the perimeter of the handle.

22. An iontophoresis device to deliver an active agent to a biological entity by forming a circuit path from a power source via two different portions of the biological entity, the iontophoresis device comprising:

a handle having a perimeter sized and configured to be grasped;

a counter electrode assembly at least partially received in the handle portion of the housing, the counter electrode assembly comprising a counter electrode element operable to supply an electrical potential of a first polarity from a power source; and

at least one active electrode assembly including a plurality of probe shaped active agent reservoirs each extending from the handle and having an exterior that is distinct from one another, and at least one active electrode element, the at least one active electrode element operable to supply an electrical potential of a second polarity, opposite to the first polarity to the active agent reservoir such that at least some active agent is driven from the active agent reservoir in response to the supply of the electrical potential of the second polarity.

23. The iontophoresis device of claim 22 wherein the active electrode element comprises a quantity of silver and wherein the active electrode assembly further comprises:

a strontium chloride active agent positioned to be delivered to a first portion of the biological entity when the active electrode element is electrically coupled to a second pole of the power source, the counter electrode is electrically coupled to a first pole of the power source and the counter electrode assembly is positioned at least proximate the second portion of the biological entity.

24. The iontophoresis device of claim 22 wherein the active electrode assembly further comprises:

a strontium chloride active agent positioned to be delivered at least proximate a tooth of the biological entity when the active electrode element is electrically coupled to a second pole of the power source, the counter electrode is electrically coupled to a first pole of the power source and the counter electrode assembly is positioned a hand of the biological entity while the handle portion is grasped by the biological entity.

25. The iontophoresis device of claim 24 wherein the strontium chloride active agent is stored in a number of probe shaped active agent reservoirs, selectively insertable in the active electrode assembly.

26. The iontophoresis device of claim 24 wherein the strontium chloride active agent is formed as a number of probe shaped gel type active agent reservoirs, selectively insertable in the active electrode assembly.

27. The iontophoresis device of claim 22 wherein probed shaped active agent reservoirs include an outermost ion selective membrane positioned to be proximate one of the portions of the biological entity when in use, and an active agent cached in the outermost ion selective membrane.

28. The iontophoresis device of claim 27 wherein the outermost ion selective membrane is an ion exchange membrane substantially selectively permeable by ions of the second polarity and substantially non-permeable to ions of the first polarity.

29. The iontophoresis device of claim 22 wherein the active electrode assembly further comprises:

a fluoride active agent positioned to be delivered at least proximate a tooth of the biological entity when the active electrode element is electrically coupled to a second pole of the power source, the counter electrode is electrically coupled to a first pole of the power source and the counter electrode assembly is positioned a hand of the biological entity while the handle portion is grasped by the biological entity.

30. An active agent delivery device to deliver an active agent to a biological entity, the active agent delivery device comprising:

a power source;

a plurality of probe means selectively positionable proximate a tooth of the biological entity for actively delivering an active agent thereto via an active current path to the power source; and

handle means selectively grippable by the biological entity for forming a return current path to the power source via the biological entity.

31. The active agent delivery device of claim 30 wherein each of the probe means comprises a probe shaped housing receiving an active electrode element electrically coupled to the power source, an electrolyte proximate the active electrode element, an active agent, and an outermost ion selective membrane exposed through the probe shaped housing to an exterior thereof.

32. The active agent delivery device of claim 31 wherein the active agent is temporarily cached in the outermost ion selective membrane.

33. The active agent delivery device of claim 31 wherein the active agent is formed as a replaceable insert comprising a quantity of strontium.

34. The active agent delivery device of claim 31 wherein the active agent is formed as a replaceable insert comprising a quantity of fluoride.

35. The active agent delivery device of claim 30 wherein each of the probe means comprises a respective probe shaped active agent reservoir.

36. The active agent delivery device of claim 35 wherein each of the probe means includes a respective an electrolyte reservoir.

37. The active agent delivery device of claim 35 wherein each of the probe means includes a respective ion selective membrane.

38. The active agent delivery device of claim 35 wherein each of the probe means share a common active electrode element electrically coupled to the power source.

39. The active agent delivery device of claim 35 wherein each of the probe means share a common electrolyte reservoir.

40. The active agent delivery device of claim 35 wherein each of the probe means share a common ion selective membrane.

41. The active agent delivery device of claim 30 wherein the handle means comprises a handle shaped housing receiving a counter electrode element electrically coupled to the power source, an electrolyte proximate the counter electrode element, and an outermost ion selective membrane exposed through the handle shaped housing to an exterior thereof.