COMBINATION CARTRIDGE AND DEVICE FOR ELECTROKINETIC DELIVERY OF MEDICAMENT TO A TREATMENT SITE

• US 20070233048A1
• Filed: 11/30/2006
• Published: 10/04/2007
• Est. Priority Date: 11/30/2005
• Status: Active Grant

• Current Assignee: Glaxo Group Limited (Glaxosmithkline Holdings Ltd.), HG Medical Technologies, LLC (Henley Ion, LLC)
• Original Assignee: Glaxosmithkline UK Limited (Glaxosmithkline Holdings Ltd.), Transport Pharmaceuticals, Inc. (NB Therapeutics)
• Inventors: Etheredge, Robert, Petersen, John, Kelland, James, Goldberg, Dennis, Jones, Anthony, Rand, Paul
• Granted Patent: US 8,321,008 B2
• Time in Patent Office: Days
• US Class Current: 604/890.100
• CPC Class Codes: A61K 9/0009 involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis microelectromechanical systems A61K9/0097
• CPC Class Codes: A61N 1/30 Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis

Abstract

A device for electrokinetic delivery of medicament to a treatment site includes a cartridge having an active electrode and a membrane overlying the active electrode and a medicament or a medicament and an electrically conductive carrier therefor, carried by the membrane in electrical contact with the electrode. The electrode opens through a surface of the cartridge remote from the membrane for connection with an electrical connector carried by the device. An locking element releasably couples the cartridge to the housing.

Claims

1. An electrokinetic delivery system for self-administration of a medicament to a treatment site on a human individual, the delivery system comprising:

a cartridge applicator device shaped in part to conform to at least a portion of a finger of the individual and including a retainer for releasably securing the applicator device to the finger, a power source or coupling thereto, and a tactile electrode;

a cartridge including a first side for supporting a medicament, a second side, opposite to the first side, facing the applicator device when the cartridge is secured to the applicator device, and an active electrode accessible through the second side from the first side, wherein the active electrode is in electrical contact with said medicament and said power source when said cartridge is secured to the applicator device,

whereby, upon application of the active electrode to the treatment site with a medicament interposed between said active electrode and the treatment site and completion of an electrical circuit through the active electrode, the medicament or a conductive carrier therefor, the treatment site, the individual'"'"'s body, the tactile electrode and the power source, said device causes an electrical current to flow for electrokinetically driving the medicament from the cartridge into the treatment site, and

a locking element carried by one of the cartridge applicator device and the second side of the cartridge and engaged with a locking surface on another one of said device and the second side of the cartridge, said locking element is movable to release the securement between the cartridge applicator device and the cartridge enabling release of the cartridge from the device.

2. An electrokinetic delivery system according to claim 1 wherein the locking element includes at least one post with a locking flat surface, and the post engages the another one of said device and the second side of the cartridge.

3. An electrokinetic delivery system according to claim 2 wherein said another of said device and second side of the cartridge includes a surface co-operable with said post.

4. An electrokinetic delivery system according to claim 1 wherein said second side of the cartridge and said device have co-operable surfaces at least one of which is deformable to abut against the other surface to forcibly eject the cartridge from the device.

5. An electrokinetic delivery system according to claim 4 wherein said co-operable elements include a pair of resilient posts carried by said one of the second side of the cartridge and the device, and tapered surfaces carried by said another of the second side of cartridge and the device.

6. An electrokinetic delivery system according to claim 5 wherein said posts engage respective locking surfaces on said another of the second side of the cartridge and said device.

7. An electrokinetic delivery system according to claim 4 wherein at least one of said co-operable elements is moveable to allow an insertion of the cartridge into the device.

8. An electrokinetic delivery system according to claim 1 wherein said cartridge includes a pair of resilient posts upstanding on the second side, and said device includes a pair of locking surfaces and a pair of tapered surfaces, said posts engaging said locking surfaces to secure the cartridge to the device and are moveable against a bias to engage the pair of tapered surfaces enabling the cartridge to be forcibly ejected from the device.

9. An electrokinetic delivery system according to claim 8 including a pair of push buttons on respective sides of the device for moving the posts against the bias to forcibly eject the cartridge from the device.

10. A coupling apparatus according to claim 1 wherein said locking element includes a rim having an underside ledge on the cartridge and a deformable latch arm having the another surface of the device, wherein the latch arm deforms while sliding into the rim and thereafter latches to the rim.

11. An electrokinetic delivery system according to claim 10 wherein said locking element includes a post having an underside ledge serving as the locking surface on the cartridge and a deformable latch arm having the another surface of the device, wherein the latch arm deforms while sliding into the rim and thereafter latches to the rim.

12. An electrokinetic delivery system according to claim 11 wherein said post and deformable latch arm cooperate to releasable lock the cartridge in the device.

13. An electrokinetic delivery system according to claim 11 wherein said locking element includes at least one post on the cartridge and a deformable latch arm extending from the another surface of the device, wherein the latch arm deforms while sliding into the rim and thereafter latches to the rim.

14. An electrokinetic delivery system according to claim 13 wherein said post is a pair of post on opposite sides of an opening in the cartridge which exposes the active electrode.

15. An electrokinetic delivery system according to claim 14 where the underside ledge of each post faces away form the opening in the cartridge.

16. An electrokinetic delivery system according to claim 1 wherein the locking element includes a weakness preventing reuse of said cartridge upon release of the cartridge from the device.

17. An electrokinetic delivery system for self-administration of a medicament to a treatment site on a human individual, said system comprising:

an applicator including a power source or coupling thereto, and a tactile electrode;

a cartridge having a first surface to receive a medicament matrix and a second surface facing the applicator when the cartridge is releasably secured to the applicator;

a locking element carried by one of the device and said second surface of the cartridge and engaged with a locking surface on another of said device and said second surface of the cartridge, said element being movable thereof to release the securement between the device and the cartridge enabling release of the cartridge from the device, said another of said device and said second surface of the cartridge includes an actuating surface co-operable with said element enabling a bias of said element to forcibly eject the cartridge from the device;

wherein said cartridge includes an active electrode extending through the second surface and to the matrix, said active electrode in electrical contact with said power source or coupling thereto when said cartridge is secured to the device whereby, upon application of the active electrode to the treatment site with a medicament interposed between said active electrode and the treatment site and completion of an electrical circuit through the active electrode, the medicament or a conductive carrier therefor, the treatment site, the individual'"'"'s body, the tactile electrode and the power source, said delivery system causes an electrical circuit to flow for electrokinetically driving the medicament from the cartridge into the treatment site.

18. A system according to claim 17 wherein said element includes a resilient post carried by said one of said second surface of the cartridge and the device and a tapered surface carried by said another of the cartridge and the device enabling forcible ejection of the cartridge from the device.

19. A system according to claim 18 wherein said post engages a locking surface on said another of said second surface of the cartridge and said device to secure the cartridge and device to one another and engages the tapered surface carried by said another of said second surface of the cartridge and said device to forcibly eject the cartridge from the device upon disengagement from the locking surface.

20. A system according to claim 19, wherein said inter-engaging element is moveable in response to relative displacement of the cartridge and device toward one another to engage the other of said element enabling the cartridge and the device for releasable securement to one another.