Neural Conduit Agent Dissemination
First Claim
1. A method of disseminating a biocompatible agent to a patient, the method comprising providing to a patient in need thereof an agent capable of exerting an effect at a distal neural site, the agent provided by a non-topical ocular route of administration for dissemination via a neural conduit to exert the effect at the distal neural site.
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Accused Products
Abstract
A method for dissemination of a biocompatible agent using a neural conduit. In one embodiment, agent dissemination is facilitated, for example, by the application of thermal energy, ultrasound energy, radiant energy, electromagnetic energy, or electrical current. As one example, agent may be provided to a sensory organ such as the eye, ear, or nose, for dissemination along the optic nerve to the central nervous system. As another example, agent may be provided at an acupuncture site for dissemination along a peripheral nerve to either a second peripheral nerve site or a central nervous system site.
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Citations
16 Claims
- 1. A method of disseminating a biocompatible agent to a patient, the method comprising providing to a patient in need thereof an agent capable of exerting an effect at a distal neural site, the agent provided by a non-topical ocular route of administration for dissemination via a neural conduit to exert the effect at the distal neural site.
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2. A method of disseminating a biocompatible agent to a patient, the method comprising providing to a patient in need thereof at a first peripheral nervous system site, an agent capable of exerting via dissemination by a neural conduit an effect at least one of a second peripheral nervous system site or a central nervous system site, the agent administered at least one acupuncture site by at least one of injection, transdermal administration, or facilitated topical administration.
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3. A method of disseminating a biocompatible agent to a patient, the method comprising providing to at least one of an oral cavity or a nasal cavity of a patient in need thereof for dissemination via a neural conduit from a Eustachian tube to at least one of a second peripheral nervous system site or a central nervous system site, an agent capable of exerting an effect at the site.
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14. A method of disseminating a biocompatible agent, the method comprising providing to an individual at a first neural site an agent selected from the group consisting of an acetylcholinestrase inhibitor, an L-type calcium channel modulator, an agonist of a nicotinic alpha-7 receptor, an inhibitor of phosphodiesterase 10, an inhibitor of phosphodiesterase 4, and combinations thereof, the agent disseminated along a neural conduit to a central nervous system site in need of therapy, the agent administered by at least one of
a non-topical ocular route, injection, transdermal application, or facilitated topical administration at least one acupuncture site, administration at an olfactory site, or pharynx or nasal administration to a Eustachian tube.
Specification