COMPOSITION FOR TOPICAL SUBSTANCE DELIVERY

• US 20070237825A1
• Filed: 04/06/2007
• Published: 10/11/2007
• Est. Priority Date: 05/30/2000
• Status: Abandoned Application

• Current Assignee: Soluble Systems LLC
• Original Assignee: Soluble Systems LLC
• Inventors: Levy, Guy, Rancourt, James, Staley, Allan
• Application Number:
  US11/697,491
• Publication Number:
  US 20070237825A1
• Time in Patent Office: Days
• US Class Current: 424/487
• CPC Class Codes: A61K 47/32 Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers , poly(meth)acrylates, or polyvinyl pyrrolidone
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: A61K 9/0048 Eye, e.g. artificial tears
• CPC Class Codes: A61K 9/06 Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels composition of ointments, creams or gels A61K47/00
• CPC Class Codes: A61L 26/0014 obtained by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 26/008 Hydrogels or hydrocolloids
• CPC Class Codes: A61P 1/00 Drugs for disorders of the alimentary tract or the digestive system
• CPC Class Codes: A61P 1/02 Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
• CPC Class Codes: A61P 17/02 for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: A61P 17/16 Emollients or protectives, e.g. against radiation
• CPC Class Codes: A61P 19/02 for joint disorders, e.g. arthritis, arthrosis
• CPC Class Codes: A61P 21/02 Muscle relaxants, e.g. for tetanus or cramps
• CPC Class Codes: A61P 25/24 Antidepressants
• CPC Class Codes: A61P 27/04 Artificial tears; Irrigation solutions
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 3/10 for hyperglycaemia, e.g. antidiabetics
• CPC Class Codes: A61P 31/04 Antibacterial agents
• CPC Class Codes: A61P 31/18 for HIV
• CPC Class Codes: A61P 39/02 Antidotes
• CPC Class Codes: A61P 5/00 Drugs for disorders of the endocrine system
• CPC Class Codes: C08F 220/20 : of polyhydric alcohols or phenols , e.g. 2-hydroxyethyl (meth)acrylate or glycerol mono-(meth)acrylate
• CPC Class Codes: C08L 33/14 : of esters containing halogen, nitrogen, sulfur, or oxygen atoms in addition to the carboxy oxygen

Abstract

A polymerized hydrogel composition for hydrating or dehydrating a surface, particularly a dermatological surface, to which it is applied and a method for forming the composition. The composition is comprised of a mixture of two polymerizable materials, a two-part redox catalyst system and a two-part polymerization medium. The percentage by weight of each element in the composition may be varied within stated percentage ranges and depending to the desired application. The rate at which hydration or dehydration occurs may be controllably altered by varying the percentages of certain of the composition elements and by adding either or both of a fibrous filler material and a humectant to the composition.

Claims

1. A microporous hydrogel composition, comprising:

a microporous hydrogel polymer formed from a polymerization composition, comprising;

a. 26-35% by weight of a hydrophilic acrylate-based monomer selected from 2-hydroxyethyl acrylate, 2-hydroxypropyl acrylate, and 2-hydroxybutyl acrylate;

b. a crosslinking agent;

c. 62-72% by weight of water;

d. up to 11% by weight of a low molecular weight aliphatic alcohol; and

,

e. a predetermined amount of a fibrous filler material having known moisture absorption characteristics.

2. The composition of claim 1, further comprising:

propylene glycol, wherein the propylene glycol is infused into the polymerized microporous hydrogel.

3. The composition of claim 2, wherein the propylene glycol is infused into the polymerized microporous hydrogel by contacting the microporous hydrogel polymer with an aqueous solution of propylene glycol.

4. The composition of claim 3, wherein the aqueous solution of propylene glycol, comprises 25-75% propylene glycol.

5. The composition of claim 3, wherein the aqueous solution of propylene glycol, comprises 25% propylene glycol.

6. The composition of claim 3, wherein the aqueous solution of propylene glycol, comprises 50% propylene glycol.

7. The composition of claim 3, wherein the aqueous solution of propylene glycol, comprises 75% propylene glycol.

8. The composition of claim 1 wherein the fibrous filler material is insoluble in water, acrylate monomers, aliphatic alcohol, and propylene glycol.

9. The composition of claim 8 wherein the fibrous filler material is comprised of polar polymers.

10. The composition of claim 8 wherein the fibrous filler material is comprised of non-polar polymers.

11. The composition of claim 8 wherein the predetermined amount of the fibrous filler material is that amount of the material which, based on the known moisture absorption capacity of the material, will achieve moisture saturation when mixed with the other polymerization composition elements.

12. The composition of claim 1, wherein the crosslinking agent is selected from ethylene glycol dimethacrylate (EGDMA), diethylene glycol dimethacrylate, trimethylpropane triacrylate, and trimethylpropane trimethacrylate.

13. The composition of claim 12, wherein the crosslinking agent is EGDMA.

14. The composition of claim 1, wherein 1-1.8% by weight of the polymerization composition is the crosslinking agent.

15. The composition of claim 14, wherein 1.3% by weight of the polymerization composition is the crosslinking agent.

16. The composition of claim 1, wherein 6.5% by weight of the polymerization composition is the alcohol.

17. The composition of claim 1, wherein the microporous hydrogel polymer comprises 0% by weight of the aliphatic alcohol.

18. The composition of claim 1, wherein the alcohol is selected from isopropyl alcohol (IPA), ethyl alcohol, and methyl alcohol.

19. The composition of claim 18, wherein the alcohol is IPA.

20. The composition of claim 1, wherein the polymerization composition further comprises:

a polymerization initiator.

21. The composition of claim 20, wherein the polymerization initiator is a thermally activated free radical initiator.

22. The composition of claim 21, wherein the thermally activated free radical initiator is 2,2′

-azobisisobutyronitrile.

23. The composition of claim 20, wherein the polymerization initiator is a redox catalyst system.

24. The composition of claim 23, wherein the redox catalyst system, comprises:

ammonium persulfate and tetramethylethylenediamine.

25. The composition of claim 24, wherein 0.4% by weight of the polymerization composition of ammonium persulfate is present and 0.2% by weight of the polymerization composition of tetramethylethylenediamine is present.

26. The composition of claim 1, wherein the monomer is 2-hydroxyethyl acrylate.

27. The composition of claim 1, wherein the monomer is 2-hydroxypropyl acrylate.

28. The composition of claim 1, wherein the monomer is 2-hydroxybutyl acrylate.

29. A microporous hydrogel composition, comprising:

(A) a microporous hydrogel polymer formed from a polymerization composition; and

,

(B) propylene glycol, wherein the propylene glycol is infused into the polymerized microporous hydrogel;

the polymerization composition, comprising;

a. 26-35% by weight of a hydrophilic acrylate-based monomer selected from 2-hydroxyethyl acrylate, 2-hydroxypropyl acrylate, and 2-hydroxybutyl acrylate;

b. a crosslinking agent;

c. 62-72% by weight of water;

d. up to 11% by weight of a low molecular weight aliphatic alcohol; and

,

e. a predetermined amount of a fibrous filler material having known moisture absorption characteristics.

30. The composition of claim 29, wherein the propylene glycol is infused into the polymerized microporous hydrogel by contacting the microporous hydrogel polymer with an aqueous solution of propylene glycol.

31. The composition of claim 30, wherein the aqueous solution of propylene glycol, comprises 25-75% propylene glycol.

32. The composition of claim 30, wherein the aqueous solution of propylene glycol, comprises 25% propylene glycol.

33. The composition of claim 30, wherein the aqueous solution of propylene glycol, comprises 50% propylene glycol.

34. The composition of claim 30, wherein the aqueous solution of propylene glycol, comprises 75% propylene glycol.

35. The composition of claim 29 wherein the fibrous filler material is insoluble in water, acrylate monomers, aliphatic alcohol, and propylene glycol.

36. The composition of claim 35 wherein the fibrous filler material is comprised of polar polymers.

37. The composition of claim 35 wherein the fibrous filler material is comprised of non-polar polymers.

38. The composition of claim 35 wherein the predetermined amount of the fibrous filler material is that amount of the material which, based on the known moisture absorption capacity of the material, will achieve moisture saturation when mixed with the other polymerization composition elements.

39. The composition of claim 29, wherein the crosslinking agent is selected from ethylene glycol dimethacrylate (EGDMA), diethylene glycol dimethacrylate, trimethylpropane triacrylate, and trimethylpropane trimethacrylate.

40. The composition of claim 39, wherein the crosslinking agent is EGDMA.

41. The composition of claim 29, wherein 1-1.8% by weight of the polymerization composition is the crosslinking agent.

42. The composition of claim 41, wherein 1.3% by weight of the polymerization composition is the crosslinking agent.

43. The composition of claim 29, wherein 6.5% by weight of the polymerization composition is the alcohol.

44. The composition of claim 29, wherein the microporous hydrogel polymer comprises 0% by weight of the aliphatic alcohol.

45. The composition of claim 29, wherein the alcohol is selected from isopropyl alcohol (IPA), ethyl alcohol, and methyl alcohol.

46. The composition of claim 45, wherein the alcohol is IPA.

47. The composition of claim 29, wherein the polymerization composition further comprises:

a polymerization initiator.

48. The composition of claim 47, wherein the polymerization initiator is a thermally activated free radical initiator.

49. The composition of claim 48, wherein the thermally activated free radical initiator is 2,2′

-azobisisobutyronitrile.

50. The composition of claim 47, wherein the polymerization initiator is a redox catalyst system.

51. The composition of claim 50, wherein the redox catalyst system, comprises:

ammonium persulfate and tetramethylethylenediamine.

52. The composition of claim 51, wherein 0.4% by weight of the polymerization composition of ammonium persulfate is present and 0.2% by weight of the polymerization composition of tetramethylethylenediamine is present.

53. The composition of claim 29, wherein the monomer is 2-hydroxyethyl acrylate.

54. The composition of claim 29, wherein the monomer is 2-hydroxypropyl acrylate.

55. The composition of claim 29, wherein the monomer is 2-hydroxybutyl acrylate.