19-Nor-Vitamin D Analogs with 1,2 or 3,2 Heterocyclic Ring
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Abstract
19-nor-vitamin D analogs having an additional heterocyclic ring connecting the 3β-oxygen and carbon-2 or the 1α-oxygen and carbon-2 of the A-ring of the analog, and pharmaceutical uses therefore, are described. These compounds exhibit significant activity in mobilization of bone, making them therapeutic agents for the treatment or prophylaxis of osteoporosis, osteomalacia, osteopenia, renal osteodystrophy and hypoparathyroidism.
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105 Claims
- 1. A compound having the formula:
- 6. A method of treating a metabolic bone disease comprising administering to a subject with said disease an effective amount of a compound having the formula:
- 20. A method of treating osteopenia comprising administering to a subject with osteopenia an effective amount of a compound having the formula:
- 29. A method of treating renal osteodystrophy comprising administering to a subject with renal osteodystrophy an effective amount of a compound having the formula:
- 38. The method of treating or preventing obesity of an animal, inhibiting adipocyte differentiation, inhibiting SCD-1 gene transcription, and/or reducing body fat in an animal comprising administering to an animal in need thereof an effective amount of a compound having the formula:
- 50. A compound having the formula:
- 55. A method of treating a metabolic bone disease comprising administering to a subject with said disease an effective amount of a compound having the formula:
- 69. A method of treating osteopenia comprising administering to a subject with osteopenia an effective amount of a compound having the formula:
- 78. A method of treating renal osteodystrophy comprising administering to a subject with renal osteodystrophy an effective amount of a compound having the formula:
- 87. A method of treating or prevention obesity of an animal, inhibiting adipocyte differentiation, inhibiting SCD-1 gene transcription, and/or reducing body fat in an animal comprising administering to an animal in need thereof an effective amount of a compound having the formula:
- 99. A compound having the formula:
- 101. A compound having the formula:
- 104. A compound having the formula:
Specification