NOVEL COMPOUNDS

• US 20070238737A1
• Filed: 03/29/2007
• Published: 10/11/2007
• Est. Priority Date: 03/31/2006
• Status: Active Grant

• Current Assignee: Glaxo Group Limited (GSK plc)
• Original Assignee: Glaxo Group Limited (GSK plc)
• Inventors: Witherington, Jason, King, Nigel
• Granted Patent: US 7,713,978 B2
• Time in Patent Office: Days
• US Class Current: 514/253.110
• CPC Class Codes: A61P 1/00 Drugs for disorders of the alimentary tract or the digestive system
• CPC Class Codes: A61P 1/04 for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
• CPC Class Codes: A61P 1/08 for nausea, cinetosis or vertigo; Antiemetics
• CPC Class Codes: A61P 1/10 Laxatives
• CPC Class Codes: A61P 1/14 Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
• CPC Class Codes: A61P 19/02 for joint disorders, e.g. arthritis, arthrosis
• CPC Class Codes: A61P 19/10 for osteoporosis
• CPC Class Codes: A61P 21/00 Drugs for disorders of the muscular or neuromuscular system
• CPC Class Codes: A61P 25/20 Hypnotics; Sedatives
• CPC Class Codes: A61P 25/28 for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 3/00 Drugs for disorders of the metabolism of the blood or the extracellular fluid A61P7/00
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 5/10 of the posterior pituitary hormones, e.g. oxytocin, ADH
• CPC Class Codes: A61P 7/00 Drugs for disorders of the blood or the extracellular fluid
• CPC Class Codes: A61P 9/04 Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
• CPC Class Codes: C07D 213/76 to which a second hetero atom is attached nitro radicals C07D213/61
• CPC Class Codes: C07D 405/12 linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 409/12 linked by a chain containing hetero atoms as chain links

Abstract

The present invention relates to compounds of formula (I) processes for their preparation, pharmaceutical compositions containing the same and to their use in the treatment of gastrointestinal and other disorders.

Claims

1. The compound N-[6-[cis-3,5-dimethyl-1-piperazinyl]-3-(methyloxy)-2-pyridinyl]-3-fluoro-4-(5-methyl-2-furanyl)benzenesulfonamide;

or a derivative thereof.

2. A pharmaceutical composition comprising a compound according to claim 1 or derivative thereof.

3. A process for the preparation of a pharmaceutical composition according to claim 2.

4. A method of treatment for conditions or disorders in a mammal which can be mediated via the growth hormone secretagogue (GHS) receptors, which comprises administering to said mammal a therapeutically safe and effective amount of the compound according to claim 1 or derivative thereof.

5. The method of claim 4 wherein said mammal is a human.

6. A method of treatment according to claim 4 wherein said conditions or disorders are selected from the group consisting of cachexia, sarcopenia, osteoporosis, rheumatoid arthritis, osteoarthritis, frailty associated with aging, growth hormone deficiency, metabolic disorder, sleep disorder, Alzheimer'"'"'s Disease, congestive heart failure, symptoms associated with gastro-esophageal reflux, symptoms associated with dyspepsia, emesis, symptoms associated with paralytic ileus, symptoms associated with pseudo-obstruction, conditions associated with constipation, and constipation-predominant irritable bowel syndrome.