INTERVENTRICULAR DELAY AS A PROGNOSTIC MARKER FOR REVERSE REMODELING OUTCOME FROM CARDIAC RESYNCHRONIZATION THERAPY
First Claim
1. A method of predicting whether a subject can reasonably be expected to experience beneficial cardiac reverse remodelling due to delivery of a cardiac resynchronization therapy (CRT), comprising:
- measuring an inter-ventricular mechanical delay (IVMD) of a heart failure patient during an episode of normal sinus rhythm (NSR); and
based at least in part upon the magnitude of the measured IVMD, predicting whether the patient can be expected to successfully experience beneficial reverse remodelling of at least a part of the patient'"'"'s heart in response CRT delivery.
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Abstract
In heart failure (HF) patients diagnosed according to the New York Heart Association (NYHA) rating scale as either Class III or Class IV, with QRS duration ≧120 ms, left ventricular (LV) EF≦35% (when in sinus rhythm), cardiac resynchronization therapy (CRT) can predict sustained improvement in at least LV structure and function. The knowledge of aetiology of a subject'"'"'s HF status and of a few simple echocardiographic characteristics provides useful information as to whether such patients and undergo significant and beneficial reverse remodelling of the LV in particular and, in the long term can be expected to experience an improvement in all-cause mortality, for example such patients can be reasonably expected to survive and enjoy a relatively enhanced quality of life (QOL). A patient who qualifies according to the invention can be termed a reverse remodelling responder (RRR) or the like.
40 Citations
20 Claims
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1. A method of predicting whether a subject can reasonably be expected to experience beneficial cardiac reverse remodelling due to delivery of a cardiac resynchronization therapy (CRT), comprising:
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measuring an inter-ventricular mechanical delay (IVMD) of a heart failure patient during an episode of normal sinus rhythm (NSR); and
based at least in part upon the magnitude of the measured IVMD, predicting whether the patient can be expected to successfully experience beneficial reverse remodelling of at least a part of the patient'"'"'s heart in response CRT delivery. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. An apparatus useful in predicting whether a heart failure (HF) patient can reasonably be expected to experience beneficial cardiac reverse remodelling due to delivery of a cardiac resynchronization therapy (CRT), comprising:
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means for measuring an inter-ventricular mechanical delay (IVMD) of a HF patient during an episode of normal sinus rhythm (NSR); and
means for predicting whether the HF patient can be expected to successfully experience reverse remodelling of at least a part of the HF patient'"'"'s heart in response to delivery of a CRT based at least in part upon the magnitude of the measured IVMD. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20)
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Specification