Method and Apparatus for Arrhythmia Episode Classification

• US 20070239043A1
• Filed: 03/30/2006
• Published: 10/11/2007
• Est. Priority Date: 03/30/2006
• Status: Abandoned Application

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Brown, Mark, Patel, Amisha, Gunderson, Bruce, Webb, James, Carlson, Dan
• Application Number:
  US11/278,001
• Publication Number:
  US 20070239043A1
• Time in Patent Office: Days
• US Class Current: 600/508
• CPC Class Codes: A61B 5/361 Detecting fibrillation
• CPC Class Codes: A61B 5/363 Detecting tachycardia or bradycardia
• CPC Class Codes: A61B 5/7264 Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems neural networks per se G06N3/00; expert systems per se G06N5/00
• CPC Class Codes: A61N 1/3622 comprising two or more electrodes co-operating with different heart regions
• CPC Class Codes: A61N 1/37211 Means for communicating with stimulators
• CPC Class Codes: A61N 1/3956 Implantable devices for applying electric shocks to the heart, e.g. for cardioversion
• CPC Class Codes: G16H 50/20 for computer-aided diagnosis, e.g. based on medical expert systems

Abstract

Apparatus and methods are provided for analyzing an episode stored by an implantable medical device (IMD) using prior probability and conditional probability information to determine the likelihood of a particular diagnosis for a given stored episode. Certain embodiments include retrieving information about a stored episode from an IMD, including an episode metric, and retrieving domain expert information about potential diagnoses and episode metrics to determine the likelihood that the stored episode was due to a particular potential diagnosis. Certain embodiments also include retrieving patient information including a patient metric, such as patient demographics, or patient history. Certain embodiments of the invention include the ability to automatically or manually update or change the domain expert information.

Claims

1. A method of analyzing an episode stored by an implantable medical device (IMD), comprising:

retrieving information about a stored episode from an IMD, the stored episode information including an episode metric;

retrieving domain expert information about one or more potential diagnoses and one or more episode metrics; and

applying the domain expert information to the episode metric to determine a likelihood that the stored episode is indicative of a particular potential diagnosis.

2. The method of claim 1 further comprising retrieving patient information including at least one patient metric.

3. The method of claim 2 wherein the patient metric identifies patient demographic information.

4. The method of claim 2 wherein the patient metric comprises historical patient information.

5. The method of claim 4 wherein the historical patient information includes information about previous stored episodes.

6. The method of claim 1 wherein domain expert information includes prior probability and conditional probability information describing the relationship between episode metrics and potential diagnoses.

7. The method of claim 6 wherein the domain expert information further includes conditional probability information describing a likelihood of one or more episode metrics being observed if a particular potential diagnosis is known to be present.

8. The method of claim 6 wherein the domain expert information further includes prior probability and conditional probability information describing the relationship between patient information and potential diagnoses.

9. The method of claim 1 wherein the potential diagnoses include both physiologic and non-physiologic causes.

10. The method of claim 9 wherein the non-physiologic causes include at least one of oversensing, electromagnetic interference (EMI), lead malfunctions, and myopotentials.

11. The method of claim 1 wherein the step of applying domain expert information to determine the likelihood that the stored episode was due to one or more potential diagnoses further comprises applying Bayes'"'"' theorem to calculate posterior probabilities of one or more of the potential diagnoses.

12. The method of claim 1 further comprising identifying a likely diagnosis by selecting the potential diagnosis with the highest posterior probability.

13. The method of claim 1 further comprising identifying a likely diagnosis by selecting the potential diagnosis that exceeds a predetermined threshold.

14. A computer-readable medium programmed with instructions for performing a method of analyzing an episode stored by an implantable medical device (IMD), the medium comprising instructions for causing a programmable processor to:

retrieve information about a stored episode from an IMD, the stored episode information including an episode metric;

retrieve domain expert information about one or more potential diagnoses and one or more episode metrics; and

apply the domain expert information to the episode metric to determine a likelihood that the stored episode was due to a particular potential diagnosis.

15. The medium of claim 14 further comprising instructions to retrieve patient information including at least one patient metric.

16. The medium of claim 14 wherein the IMD is a cardiac rhythm management (CRM) device, and wherein potential diagnoses include cardiac arrhythmia classifications.

17. The medium of claim 14 further comprising instructions to include non-physiologic causes among the potential diagnoses.

18. The medium of claim 14 further comprising instructions to apply Bayes'"'"' theorem to calculate posterior probabilities of one or more of the potential diagnoses using the following equation:

P(D₁|S₁, S₂)=P(S₁, S₂|D₁)*[P(D₁)/P(S₁, S₂)],

where P(S₁, S₂|D₁) is the conditional probability that episode metrics S₁ and S₂ will both be observed if the diagnosis is known to be D₁, and

where P(D₁) and P(S₁, S₂) are the prior probabilities of D₁ occurring, and of both S₁ and S₂ occurring, respectively.

19. The medium of claim 14 further comprising instructions to identify a likely diagnosis by selecting the potential diagnosis with the highest posterior probability.

20. The medium of claim 14 further comprising instructions to identify a likely diagnosis by selecting the potential diagnosis that exceeds a predetermined threshold.

21. A system for analyzing episodes stored by an implantable medical device (IMD), the system comprising:

retrieval means for retrieving stored episodes from an IMD, the stored episodes including one or more episode metrics;

informational retrieval means for retrieving domain expert information about one or more potential diagnoses and one or more episode metrics; and

a processor for determining a likelihood that a given stored episode was due to a particular diagnosis, wherein information retrieval means is adapted to receive domain expert information automatically via a network, and wherein the processor is adapted to determine the likelihood of a particular diagnosis by calculating a posterior probability according to the equation;

P(D₁|S₁, S₂)=P(S₁, S₂|D₁)*[P(D₁)/P(S₁, S₂)],

wherein P(S₁, S₂|D₁) is the conditional probability that episode metrics S₁ and S₂ will both be observed if the diagnosis is known to be D₁, and wherein P(D₁) and P(S₁, S₂) are the prior probabilities of D₁ occurring, and of both S1 and S₂ occurring, respectively.

22. The system of claim 21 further adapted to allow manual modification of the domain expert information.

23. The system of claim 21 wherein the domain expert information may be modified based on episode information from previously stored episodes.

24. The system of claim 21 wherein the retrieval means for retrieving stored episodes from an IMD includes a programmer.

25. The system of claim 21 wherein the retrieval means for retrieving stored episodes from an IMD includes a computer network.