Modulation of intracellular calcium concentration using non-excitatory electrical signals applied to the tissue
First Claim
1. A method of modulating intracellular calcium concentration in biological tissue, which comprises the steps of:
- (a) applying a stimulation probe to biological tissue;
(b) generating a non-excitatory stimulation pulse; and
(c) conveying the pulse to the stimulation probe.
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Accused Products
Abstract
According to a method and device for modulating intracellular calcium concentration in biological tissue, a stimulation probe is applied to the tissue, a non-excitatory stimulation pulse is generated, and the pulse is conveyed to the stimulation probe. In one embodiment concerning cardiac tissue, a stimulation probe is applied to a patient'"'"'s heart, a signal is received from at least one sensor responsive to the patient'"'"'s cardiac muscle activity, a non-excitatory stimulation pulse responsive to the signal is generated, and the pulse is conveyed to the stimulation probe.
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Citations
58 Claims
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1. A method of modulating intracellular calcium concentration in biological tissue, which comprises the steps of:
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(a) applying a stimulation probe to biological tissue;
(b) generating a non-excitatory stimulation pulse; and
(c) conveying the pulse to the stimulation probe. - View Dependent Claims (2, 3, 4)
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5. A method of modulating intracellular calcium concentration in cardiac tissue, comprising:
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(a) applying a stimulation probe comprising one or more stimulation electrodes to a subject'"'"'s heart;
(b) receiving a signal from at least one sensor responsive to the subject'"'"'s cardiac muscle activity;
(c) generating a non-excitatory stimulation pulse responsive to the signal; and
(d) conveying the pulse to at least one of the one or more electrodes. - View Dependent Claims (6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29)
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30. An apparatus for modulating intracellular calcium concentration in biological tissue, comprising:
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a stimulation probe, and an electrical control unit capable of generating a non-excitatory stimulation pulse and conveying said pulse to the stimulation probe to modulate intracellular calcium concentration. - View Dependent Claims (31, 32, 33)
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34. An apparatus for modulating intracellular calcium concentration in cardiac tissue, comprising:
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a stimulation probe comprising one or more stimulation electrodes, at least one sensor capable of generating a signal responsive to cardiac activity, and an electrical control unit capable of generating a non-excitatory stimulation pulse responsive to the signal and conveying said pulse to at least one or the one or more stimulation electrodes to modulate intracellular calcium concentration. - View Dependent Claims (35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58)
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Specification