Oscillation assisted drug elution apparatus and method

• US 20070239253A1
• Filed: 04/06/2006
• Published: 10/11/2007
• Est. Priority Date: 04/06/2006
• Status: Abandoned Application

• Current Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Inventors: Jagger, Karl, Shippy, James
• Application Number:
  US11/398,670
• Publication Number:
  US 20070239253A1
• Time in Patent Office: Days
• US Class Current: 623/1.110
• CPC Class Codes: A61F 2/82 Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95; for closing wounds, or holding wounds closed A61B17/04 - A61B17/115; dilators A61M29/00
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61N 7/00 Ultrasound therapy lithotripsy A61B17/22, A61B17/225; massage using supersonic vibration A61H23/00 ; using ultrasound for introducing media into the body A61M37/0092

Abstract

An apparatus includes a base and a coating disposed on the base. A therapeutic agent is disposed on at least one of the base or the coating. A vibration device is coupled to the base. The vibration device is configured to cause movement of the base such that at least a portion of the therapeutic agent is released from the base or the coating. A method includes inserting a stent into a body lumen of a patient. The stent has a base, a coating disposed on at least a portion of the base, and a therapeutic agent carried by at least one of the base or the coating. The stent is vibrated such that at least a portion of the therapeutic agent is released from the stent.

Claims

1. An apparatus, comprising:

a base;

a coating disposed on the base;

a therapeutic agent disposed on at least one of the base or the coating; and

a vibration device coupled to the base, the vibration device configured to cause movement of the base such that at least a portion of the therapeutic agent is released from the at least one of the base or the coating.

2. The apparatus of claim 1, wherein the vibration device is configured to vibrate the base at a resonance frequency associated with the base.

3. The apparatus of claim 1, wherein the vibration device includes a plurality of oscillators disposed at selected locations on the base such that, upon activation of the vibration device, the base vibrates at a resonance frequency associated with the base.

4. The apparatus of claim 1, wherein the vibration device is configured to vibrate the base such that the therapeutic agent is released from the at least one of the base or coating at a rate different from a rate of release associated with the therapeutic agent without being vibrated.

5. The apparatus of claim 1, wherein the base and the vibration device are dimensioned such that the base and the vibration device collectively can be disposed within a body lumen of a patient, the vibration device being configured to be remotely activated.

6. The apparatus of claim 1, wherein the vibration device includes a wire coupled to a power source.

7. A method, comprising:

inserting a stent into a body lumen of a patient, the stent having a base, a coating disposed on at least a portion of the base, and a therapeutic agent carried by at least one of the base or the coating; and

vibrating the stent such that at least a portion of the therapeutic agent is released from the stent.

8. The method of claim 7, wherein the vibrating is prior to the inserting the stent into the body lumen of the patient.

9. The method of claim 7, wherein the vibrating is after the inserting the stent into the body lumen of the patient.

10. The method of claim 7, wherein the stent further includes a vibration device coupled to the base, the method further comprising applying energy to the vibration device, the stent vibrating in response to the applying.

11. The method of claim 7, further comprising:

inserting a balloon in a collapsed configuration into a lumen of the stent, a vibration device being coupled to the balloon; and

activating the vibration device, the stent vibrating in response to the activating.

12. The method of claim 7, wherein the stent further includes a vibration device coupled to the base, the vibration device being coupled to a power source, and the vibrating includes sending a signal remotely from the power source to the vibration device.

13. The method of claim 7, wherein the apparatus further includes a vibration device coupled to the base, the vibration device includes an oscillator, a wire coupled to the oscillator and a power source;

and

the vibrating includes applying energy to the oscillator remotely from the power source.

14. The method of claim 7, wherein the vibrating includes vibrating the stent at a resonance frequency associated with the base.

15. The method of claim 7, further comprising:

measuring remotely restenosis of the body lumen prior to the vibrating the stent; and

the vibrating including vibrating remotely the stent for a time period based on the measure of restenosis after the inserting the stent into the body lumen.

16. A method, comprising:

inserting a stent into a body lumen of a patient, the stent having a base, a coating, and a therapeutic agent;

disposing a balloon in a collapsed configuration into a lumen of the stent in a collapsed configuration, the balloon coupled to a vibration device;

expanding the balloon while disposed within the lumen of the stent; and

activating the vibration device such that the stent vibrates at a resonance frequency associated with the base and such that at least a portion of the therapeutic agent is released from the stent and into the body lumen of the patient.

17. The method of claim 16, wherein the vibration device includes an oscillator coupled to the balloon, and

the activating includes remotely sending an activation signal to the oscillator.

18. The method of claim 16, wherein the vibration device includes an oscillator coupled to the balloon, a wire coupled to the oscillator, and a power source, and

the activating includes sending an activation signal from the power source to the oscillator via the wire.

19. The method of claim 16, further comprising:

activating the vibration device prior to the inserting such that at least a portion of the therapeutic agent is released from the stent.

20. An apparatus, comprising:

a base;

a coating disposed on the base;

a therapeutic agent disposed on at least one of the base or the coating;

a balloon removably coupled to the base; and

a vibration device coupled to the balloon, the vibration device configured to cause movement of the base such that at least a portion of the therapeutic agent is released from the at least one of the base or the coating.

21. The apparatus of claim 20, wherein the vibration device is configured to vibrate the base at a resonance frequency associated with the base.

22. The apparatus of claim 20, wherein the vibration device includes a plurality of oscillators disposed at selected locations on the balloon such that, upon activation of the vibration device, the base vibrates at a resonance frequency associated with the base.

23. The apparatus of claim 20, wherein the vibration device is configured to vibrate the base such that the therapeutic agent is released from the at least one of the base or the coating at a rate different from a rate of release associated with the therapeutic agent without being vibrated.

24. The apparatus of claim 20, wherein the base and the vibration device are dimensioned such that the base and the vibration device collectively can be disposed within a body lumen of a patient, the vibration device being configured to be remotely activated.