Blood Analyte Determinations
First Claim
1. An apparatus for measuring an analyte in blood taken from a patient, comprising;
- a. An analyte measurement system;
b. A fluidics system, adapted to remove blood from a body, transport a portion of the removed blood to the analyte measurement system for measurement, infuse a portion of the blood measured by the analyte measurement system back into the patient, flow a maintenance substance to the analyte measurement system without infusing a substantial amount of the maintenance substance into the patient, and flow at least a portion of the maintenance substance from the analyte measurement system to a waste channel.
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Abstract
The present invention comprises methods and apparatuses that can provide measurement of glucose and other analytes with a variety of sensors without many of the performance-degrading problems of conventional approaches. An apparatus according to the present invention comprises a blood access system, adapted to remove blood from a body and infuse at least a portion of the removed blood back into the body. Such an apparatus also comprises an analyte sensor, mounted with the blood access system such that the analyte sensor measures the analyte in the blood that has been removed from the body by the blood access system. A method according to the present invention comprises removing blood from a body, using an analyte sensor to measure an analyte in the removed blood, and infusing at least a portion of the removed blood back into the body. The use of a non-contact sensor with a closed system creates a system will minimal infection risk.
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Citations
33 Claims
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1. An apparatus for measuring an analyte in blood taken from a patient, comprising;
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a. An analyte measurement system; b. A fluidics system, adapted to remove blood from a body, transport a portion of the removed blood to the analyte measurement system for measurement, infuse a portion of the blood measured by the analyte measurement system back into the patient, flow a maintenance substance to the analyte measurement system without infusing a substantial amount of the maintenance substance into the patient, and flow at least a portion of the maintenance substance from the analyte measurement system to a waste channel. - View Dependent Claims (2, 3, 4, 5)
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6. An apparatus for determining an analyte property in blood, comprising:
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a. a blood removal element, adapted to communicate blood with the circulatory system of a patient; b. a fluid junction having three ports in fluid communication with each other, the first port in fluid communication with the blood removal element; c. a source of maintenance fluid; d. a channel for waste; e. an analyte sensor having first and second fluid ports; f. a first fluid control system, in fluid communication with and adapted to control fluid flow between the second port of the junction, the first port of the analyte sensor, and the source of maintenance fluids; g. a second fluid control system, in fluid communication with and adapted to control fluid flow between the third port of the junction, the second port of the analyte sensor, and the waste channel. - View Dependent Claims (7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31)
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32. A blood access system comprising:
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a. A junction in fluid communication with a catheter; b. A first pinch valve in fluid communication with a first side of the junction; c. A second pinch valve in fluid communication with a second side of the junction; d. An analyte sensor in fluid communication with the first pinch valve and the second pinch valve; e. A first pump in fluid communication with the first pinch valve and the analyte sensor; f. A second pump in fluid communication with the second pinch valve and the analyte sensor; g. A maintenance fluid container connection in fluid communication with the firs pump; and h. A waste channel in fluid communication with the second pump.
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33. A blood access system comprising:
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a. A junction in fluid communication with a catheter; b. A first pinch valve having a first side in fluid communication with a first side of the junction; c. A second pinch valve having a first side in fluid communication with a second side of the junction; d. A first intermediate fluid section in fluid communication with a second side of the first pinch valve; e. A second intermediate fluid section in fluid communication with a second side of the second pinch valve; f. An analyte sensor having a first side in fluid communication with the first intermediate fluid section and having a second side in fluid communication with the second intermediate fluid section; g. A first pump having a first side in fluid communication with the first intermediate fluid section; h. A second pump having a first side in fluid communication with the second intermediate fluid section; i. A maintenance fluid container connection in fluid communication with a second side of the first pump; and j. A waste channel in fluid communication with a second side of the second pump.
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Specification